Hoffmann-la Roche Inc.

Shionogi Company Limited

F. Hoffmann-la Roche Ag

Steffen Wildum

Takao Shishido

Takeshi Noshi

Yoshinori Ando

Klaus Kuhlbusch

Takahiro Noda

Barry Clinch

Jan Michal Nebesky

Kaoru Baba

Annabelle Lemenuel

Wendy S Barclay

Aeron C Hurt

Jean-Eric Charoin

Ryu Yoshida

Leo Yi Yang Lee

Hong Shen

Guang Yang

Lu Gao

Isabel Najera

Fang Shen

Liping Shi

Annabelle Lemenuel-Diot

Michael J Nebesky

The present invention relates to a method for preventing transmission of influenza, wherein said method comprises administering an effective amount of a compound to a patient having an influenza virus infection, herein referred to as 'index patient', wherein the compound has one of the formulae (I) and (II), or its pharmaceutically acceptable salt. The compound to be used in the present invention reduces infectivity of the influenza virus of the index patient, and therefore, reduces the risk of the index patient to trigger an influenza epidemic or an influenza pandemic as compared to a control patient. Therefore, one aspect of the present invention relates to a method for preventing an influenza epidemic or an influenza pandemic, wherein the method comprises administering an effective amount of a compound to patients having an influenza virus infection (index patients), wherein the compound is administered to at least 10% of all influenza infected persons of a city's or country's population, and wherein the compound has one of the formulae (I) and (II), or is a pharmaceutically acceptable salt thereof.

Compound and method for the prevention of transmission of influenza virus

The present invention is directed to compositions and methods for treating hepatitis B virus infection. In particular, the present invention is directed to a combination therapy comprising administration of an HBV capsid assembly inhibitor and an interferon for use in the treatment of hepatitis B virus infections.

Combination therapy of an HBV capsid assembly inhibitor and an interferon

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Basel, Switzerland

Steffen Wildum