Evonik Degussa Gmbh

Evonik Operations Gmbh

Cargill Inc.

Evonik Roehm Gmbh

Evonik Industries Ag

Technische Universitat Munchen

Evonik Rohm Gmbh

Steffen Schaffer

Mirja Wessel

Thomas Haas

Hans-Georg Joerg Hennemann

Anja Thiessenhusen

Christoph Schorsch

Harald Haeger

Martin Schilling

Markus Poetter

Liv Reinecke

Heiko Andrea

Mike Farwick

Arne Skerra

Hans Henning Wenk

Eckhard Boles

Jan Christoph Pfeffer

Markus Pötter

Fabien Louis Cabirol

Martin Roos

Achim Marx

Hans H Liao

Petra Allef

Oliver Thum

Marco Alexander Van Den Berg

Wolfgang Kroutil

Wendy Kathleen Ribble

Tanya Lipscomb

Tim Koehler

Christian Hartung

Gerda Grund

Friedrich Georg Schmidt

Ralf Meier

Dirk Kuppert

Ulrike Kottke

Klaus-Dieter Vorlop

Eileen Spindler

Katrin Grammann

Jan Wolter

Catherine B Poor

Tim Köhler

Kathrin Daniela Brandt

Stefan Verseck

Matthias Orschel

Florian Klasovsky

Andreas Schmid

Harald Häger

Werner Freitag

Frank Erhardt

Juergen Lattich

Christian Gehring

Wilfried Blümke

Jasmin Gielen

Nadine Stein

Ronald J Evans

Anne Jeremias

Jasmin Corthals

Thomas Hueller

Simon Beck

Peter Duerre

Philip Engel

Bruno Buehler

Brittany Prather

Brittany Robinson

Maciej Olek

Stefan Julian Liebig

Michael Volland

Anja Hecker

Alexandra Lerchner

Hubert Johannes Bahl

David A Hogsett

Antje May

Jürgen Lattich

Bruno Bühler

Eva-Maria Eckl

Ralf-Joerg Fischer

Sabine Hafkemeyer

Dave A Hogsett

Thomas Bülter

Wilfried Bluemke

Michaela Hauberg

Johann H Sattler

Katharina Christin Tauber

Daniel Wolff

Frank Ter Veld

Ansgar Poetsch

Katharina Berse

Marion Schiebelhut

Magdalena Volk

Mattijs Kamiel Julsing

Ludwig Kirmair

Manfred Schrewe

Sjef Cornelissen

Friedrich-Georg Schmidt

Wilfried Schmidt

Simone Lederle

Markus Buchhaupt

Daniel Boergel

Peter Dürre

Wilhelm Bruegging

The invention relates to a mixture composition comprising glucolipids, to its use for producing formulations and to formulations comprising this mixture composition.

Mixture composition comprising glucolipids

The invention relates to cells which make rhamnolipids and are genetically modified such that they have a decreased activity, compared to the wild type thereof, of a glucose dehydrogenase and to a method for producing rhamnolipids using the cells according to the invention.

Rhamnolipid-producing cell having reduced glucose dehydrogenase activity

The present invention relates to at least one cell for producing at least one lipid with general formula II from at least one carbon substrate, wherein Rand Rindependently of one another comprises identical or different organic radicals each with 5 to 13 carbon atoms,wherein the cell is a non-pathogenic cell that is genetically modified to increase the heterologous expression relative to the wild type cell of:

Lipid production

The present invention relates to a compound of general formula I  The present invention also relates to a method of producing N-acetyl homoserine and/or derivatives thereof, the method comprising

N-acetyl homoserine

There is provided a microbial cell expressing a mutant AlkB enzyme, the mutant AlkB enzyme comprising at least one point mutation in the wild type sequence of AlkB, wherein the point mutation is at amino acid position V129 and/or T136 of the wild type AlkB enzyme. There is also provided a method for producing omega-hydroxy carboxylic acid and/or ester thereof using this cell.

Microorganism expressing mutant AlkB enzyme and use to prepare omega-hydroxy carboxylic acid and/or ester

A microbial cell, which is genetically modified to increase the expression relative to the corresponding genetically unmodified cell of an AlkB alkane hydroxylase (E) having an amino acid sequence at least 95% identical with the amino acid sequence of SEQ ID NO: 1 and a wax-ester synthase (E) having an amino acid sequence at least 95% identical with the amino acid sequence of SEQ ID NO: 2. The cell does not have a genetic modification that increases formation of a carboxylic acid or a carboxylate ester from a simple carbon source.

Biotechnological production of omega-functionalised carboxylic acids and esters thereof

The invention provides a process for reacting a carboxylic acid ester of the formula (I)R-A-COOR&#x2003;&#x2003;(I),

Process for reacting a carboxylic acid ester

A microbial cell is used for producing at least one fatty acid ester, wherein the cell is genetically modified to contain (i) at least one first genetic mutation that enables the cell to produce at least one fatty acid and/or acyl coenzyme A (CoA) thereof by increased enzymatic activity in the cell relative to the wild type cell of malonyl-CoA dependent and malonyl-ACP independent fatty acyl-CoA metabolic pathway, wherein the fatty acid contains at least 5 carbon atoms; and (ii) a second genetic mutation that increases the activity of at least one wax ester synthase in the cell relative to the wild type cell and the wax ester synthase has sequence identity of at least 50% to a polypeptide of SEQ ID NO: 1-8 and combinations thereof or to a functional fragment of any of the polypeptides for catalyzing the conversion of fatty acid and/or acyl coenzyme A thereof to the fatty acid ester.

Production of fatty acids esters

The invention relates to a mixture composition comprising rhamnolipids, to a process for its preparation, to its use for producing formulations and to formulations comprising this mixture composition.

Mixture composition comprising rhamnolipids

The present invention relates to a method of preparing at least one rhamnolipid comprising:

Methods of producing rhamnolipids

The invention relates to a cell which has been genetically modified so as to be capable of producing more 2-hydroxyisobutyric acid or more polyhydroxyalkanoates containing 2-hydroxyisobutyric acid monomer units than its wild type, characterized in that 2-hydroxyisobutyric acid or polyhydroxyalkanoates containing 2-hydroxyisobutyric acid monomer units are produced via acetoacetyl-coenzyme A as intermediate and 3-hydroxybutyryl-coenzyme A as precursor.

Recombinant cell producing 2-hydroxyisobutyric acid

A process for producing alanine, including culturing a cell under aerobic conditions in an aqueous phase in the presence of an inorganic nitrogen source, and then contacting the aqueous phase and the cell cultured in the aqueous phase with a hydrophobic organic phase. The cell is a prokaryotic or a lower eukaryotic cell and expresses a recombinant alanine dehydrogenase.

Method for aerobically producing alanine or a compound produced using alanine

The invention relates to a whole-cell catalyst which expresses a recombinant &#x3b1;-dioxygenase or the combination of a recombinant fatty acid reductase and a phosphopantetheinyl transferase which phosphopantetheinylates the fatty acid reductase, and which expresses, in addition to the &#x3b1;-dioxygenase and/or the combination of fatty acid reductase and phosphopantetheinyl transferase, a transaminase, wherein the phosphopantetheinyl transferase and/or transaminase is preferably recombinant; and also to a process for converting a carboxylic acid or dicarboxylic acid or a monoester thereof to an amine or diamine, comprising the steps of contacting the carboxylic acid or dicarboxylic acid or the monoester thereof with a phosphopantetheinylated fatty acid reductase or an &#x3b1;-dioxygenase and contacting the product with a transaminase.

Producing amines and diamines from a carboxylic acid or dicarboxylic acid or a monoester thereof

The invention provides a whole cell catalyst which expresses a recombinant &#x3b1;-dioxygenase or the combination of a recombinant fatty acid reductase and a phosphopantetheinyl transferase phosphopantetheinylating the fatty acid reductase, and which in addition to the &#x3b1;-dioxygenase and/or the combination of fatty acid reductase and phosphopantetheinyl transferase expresses a transaminase, characterized in that the phosphopantetheinyl transferase and/or transaminase is preferably recombinant; and a method for the conversion of a fatty acid, &#x3c9;-hydroxy fatty acid, &#x3c9;-oxo fatty acid or a monoester thereof to an amine, comprising oxidation of the fatty acid, &#x3c9;-hydroxy fatty acid, &#x3c9;-oxo fatty acid or the monoester thereof to an oxidation product by contacting with an alkane hydroxylase and/or alcohol dehydrogenase, contacting the oxidation product with a phosphopantetheinylated fatty acid reductase or a &#x3b1;-dioxygenase to give an aldehyde, and contacting the aldehyde with a transaminase.

Production of omega-amino fatty acids

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Herten, Germany

Steffen Schaffer