Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V.

Whitehead Institute for Biomedical Research

Pepticom Ltd.

Steffen Rupp

Anke Burger-Kentischer

Brian Cali

Amir Sherman

Peter Hecht

Eric F Summers

Laura Robertson

Radclyffe Roberts

Hiten Madhani

Hsiu-Jung Lo

Herwig Brunner

Gerald R Fink

Thomas Schiestel

Achim Weber

Karin Lemuth

Cora Ann Styles

Günter Tovar

Heike Mertsching

Heike Walles

Kai Sohn

Immanuel Lerner

Amit Michaeli

Gerald L Fink

Nicole Hauser

Franz-Josef Johannes

Xin Xiong

Michaela Kaufmann

Doris Finkelmeier

Ina Hogk

Sonja Weishaupt

Heike Prof Walles

Henrike Lotz

A group of peptides is provided which activate or inhibit toll-like receptor 4 (TLR4) and may be used to modulate inflammatory signaling and host defense pathways. The peptides were derived in silico and tested in vitro in cell cultures. These peptides may be used in the preparation of immunomodulatory compositions such as vaccine adjuvants and in pharmaceutical compositions for immunomodulation of the innate immune system such as vaccine adjuvants. The peptides may also be used in the preparation of TLR4 activators, TLR4 inhibitors and MD2 labels, e.g., for research purposes.

Peptide agonists and antagonists of TLR4 activation

The invention relates to a competitive immunoassay test system as well as a method to simply and rapidly detect pyrogens contained in a sample by means of the pyrogen binding domain of pattern recognition receptors. The test system comprises an assay carrier having at least one immobilized pyrogen binding domain of a pattern recognition receptor with a labeled, displaceable ligand, wherein the displacement of the ligand is indicated by a pyrogen contained in the sample by a color reaction of the labeling. The assay carrier preferably also has at least one immobilized ligand capture protein, which binds the displaced ligand and thereby initiates a color reaction of the labeling.

Competitive immunoassay test system for detecting a pyrogen

The invention relates to a multi-layered biological in vitro tissue containing: dermis layer, containing a collagen biomatrix with fibroblasts embedded therein and epidermis layer, containing epithelial cells. It is provided that latently virally infected neuronal cells are integrated at least into the dermis layer.

In vitro test system for viral infections

The present invention concerns isolated collagen, the method for its production, and isolation of the collagen from collagen-containing tissues, as well as the use of the isolated collagen in a biomatrix as an in vitro test system, tissue replacement or organ replacement.

Isolated nature-identical collagen

The present invention relates to biochips, in particular nucleotide chips, which contain hyphen-specific proteins coding nucleotides, protein chips which contain hyphen-specific proteins, and antibody chips which contain antibodies directed against these hyphen-specific proteins, diagnostic compositions which contain these nucleotide, protein, or antibody chips, processes for the location and identification of substances which are therapeutically effective against diseases caused by types ofand processes for the diagnosis of a disease caused by

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Disclosed herein are methods for regulating fungal gene expression, and reagents for carrying out those methods.

Regulation of fungal gene expression

Growing community of inventors

Stuttgart, Germany

Steffen Rupp