Novo Nordisk A/s

Steffen Kidal

Peter Madsen

Anders Klarskov Petersen

Claus Ulrich Jessen

Thomas Budde Hansen

Caspar Christensen

Rune Severinsen

Henrik Valore

Tina Moeller Tagmose

Tina Møller Tagmose

Arne Staby

Jan Lindy Sørensen

Jan Lindy Soerensen

Camilla Kornbeck

Jan Lindy SØRENSEN

Described are methods for determination of peptide specific parameter(s) of a mixture comprising a target peptide and a related impurity (or impurities) to be used in a simulation model of chromatographic separation using mathematical model(s). Also described are chromatographic simulation methods using above determined parameters, as well as computer systems and computer programs for performing one or more of the above method(s).

Methods of optimizing chromatographic separation of polypeptides

A method for selectively acylating an amino group in a peptide or protein which has two or more reactive nucleophilic functional groups is described.

Method of acylating a peptide or protein

A method has for selectively acylating an amino group in a peptide or protein which has two or more reactive nucleophilic functional groups is described.

Method for purifying a racemized polypeptide by ion-exchange chromatography.

Separation of polypeptides comprising a racemized amino acid

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Koebenhavn, Denmark

Steffen Kidal