Crc Ep, Inc.

Steffen Holzinger

Dorin Panescu

Henning Ebert

Alan De La Rama

Cary K Hata

Tho Hoang Nguyen

Sven Bode

The present invention relates to a generator (G) for a substantially charge-balanced pulse for application onto at least one electrode pair () of a medical device, the generator comprising: a pulse-shaping output stage (POS) for coupling to the at least one electrode pair; an internal pulse generator for applying an internal pulse to the pulse-shaping output stage; wherein the pulse-shaping output stage comprises a transformer (T) and/or a capacitor system (CS) comprising at least one capacitor such that the internal pulse is transformed into a substantially charge-balanced pulse in the at least one electrode pair (I) when coupled to the pulse-shaping output stage (POS). Further aspects relate to a catheter, a system, a method.

Systems and methods for pulsed-field ablation with charge-balanced waveforms

The invention relates to an ablation catheter for treatment of a patient's tissue, for example for a PVI procedure on a patient's heart, comprising an elongated catheter shaft and an ablation portion being arranged at a distal end of the catheter shaft with a plurality of electrodes accommodated along the ablation portion, wherein the ablation portion comprises at least two loop sections forming a three-dimensional spiral. In order to increase safety of ablation treatment, spare adjacent tissue (e.g. nerves, vessels, esophagus) and shorten ablation time, a pitch, or clearance of two neighboring loop sections is greater than an ionization threshold of the medium around the distal section, for example blood or gases resulted from electrolysis. The invention further relates to an operation method of such ablation catheter.

Ablation catheter and operation method of same

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Berlin, Germany

Steffen Holzinger