Novo Nordisk A/s

Other

Nna/s

Noro Nordisk A/s

Nova Nordisk A/s

Steffen Hansen

Simon Roervig

Thomas Dedenroth Miller

Claus Schmidt Moller

Peter Christian Klitgaard

Simon Munch Pedersen

Henrik Bengtsson

Bo Radmer

Jan Harald Preuthun

Ole Christian Nielsen

Niels Christian Egholm Sorensen

Christian Peter Klitgaard

Carsten Schau Andersen

Nikolaj Eusebius Jakobsen

Jim Radmer

Brian Mouridsen

Erik Winkel Ethelfeld

Leif Johannsen

Claude Teisen-Simony

Bjorn Gullak Larsen

Willem Van Der Beek

Roger Harrington

Philip Albert Sparholt

Simon Rorvig

Bjørn Gullak Larsen

Finn Jensen

Claus Schmidt M&oslash;ller

S&oslash;ren Steenfeldt-Jensen

Gabriel Jo Slashedrgensen

Soren Steenfeldt-Jensen

Torben Strøm Hansen

Christian Sorensen

So Slashedren Steenfeldt-Jensen

Simon RØRVIG

Gabriel Jorgensen

A device for administering a fluid medicament by injection comprises a dosing portion () with a collapsible reservoir (). The reservoir () has a maximum volume in an extended state and a minimum volume in a collapsed state. Prior to injection, the reservoir () is in the extended state and contains a liquid to be administered, and the reservoir () is biased towards the collapsed state. The device further comprises a needle (), wherein a lumen () of the needle () is in fluid communication with the reservoir (). The device further comprises a shield portion () with a plug (). Prior to injection, the shield portion () is in a deployed position where the plug () blocks the lumen () of the needle (). The shield portion () is adapted to move in response to an actuation force from the deployed position to a retracted position where the lumen () of the needle () is open, thereby causing the reservoir () to shift to the collapsed state to expel the liquid through the needle.

Drug delivery device with a hydraulic trigger mechanism

The invention provides a pen-type injection device () with a piston rod brake mechanism for improving the determination of an expelled dose.

Piston rod brake mechanism

The present invention provides a method of manufacturing a prefilled drug delivery device comprising the steps of arranging a piston rod member () and a piston rod guide () in a housing () such that the piston rod member extends through a guide structure () fixed in the housing and is surrounded by and operatively coupled with the piston rod guide, whereby rotation of the piston rod guide in a first direction relative to the housing causes distal movement of the piston rod member relative to the guide structure, and vice versa, and rotation of the piston rod guide in a second direction relative to the housing causes proximal movement of the piston rod member relative to the guide structure, and vice versa, and the piston rod guide is in a first state being capable of bi-directional rotation with respect to the housing, bringing a displaceable wall () of a variable volume drug reservoir () into abutment with a distal end portion of the piston rod member, moving the variable volume drug reservoir proximally relative to the housing to a completely mounted position, and shifting the piston rod guide irreversibly to a second state in which rotation of the piston rod guide in the second direction relative to the housing is prevented.

Method of manufacturing prefilled drug delivery devices

The present invention relates to an injection device for automatic torsion spring driven injection of a liquid drug. The injection device is of the type wherein a telescopically movable needle shield activates the release of the torque of the torsion spring to drive the injection when the needle shield is moved from its extended position to a retracted position. The injection device further has a needle holder carrying the injection needle, which needle holder is axially movable both in relation to the housing and in relation to the needle shield. It is therefore possible to retract the needle shield in relation to the housing and at the same time move the needle holder to its extended position such that the injection needle is presented outside the needle shield thereby providing for easy exchange of the injection needle.

Spring driven injection device

The present invention relates to a torsion spring driven injection device for delivering multiple set doses of a liquid drug from a cartridge by moving a plunger forward inside the cartridge. The torsion spring () applies a rotational torque onto a drive member () engaging a piston rod () which is then driven forward by this rotation. The piston rod driver can be coupled and de-coupled from the torsion spring mechanism. In the de-coupled position, the piston rod driver is freely rotatable and can thus rotate if the piston rod is moved axially. A further torsion arrangement () is preferably provided such that a torque is build up between the piston rod driver and the housing whenever the piston rod is moved backwards. This torsion arrangement urges the piston rod driver to rotate in a direction bringing the piston rod forward into abutment with the plunger.

The present invention relates to a torsion spring based automatic injection device for apportioning set doses of a liquid drug and which injection device is provided with an End-of-Dose feedback mechanism providing a user with an audible signal once the set dose has been injected. During injection, the scale drum rotates back to its 'zero' position under influence of the torsion spring. This rotation is halted shortly before reaching the 'zero' position by stopping means. The scale drum is thereafter only allowed to continue rotation and thus reach the &#x201c;zero&#x201d; position once the torque applied to the scale drum by the torsion spring surpasses a threshold value.

Torsion spring injection device having an end-of-dose mechanism

The present invention relates to an injection device for automatic torsion spring driven injection of a liquid drug. The injection device is of the type wherein a telescopically movable needle shield () activates the release of the torque of the torsion spring to drive the injection when the needle shield is moved from its extended position to a retracted position. The injection device is provided with a needle interface () carrying the injection needle, which needle interface is provided with means () preventing axial movement of the shield when no injection needle is mounted. Further, other means are provided to restrain the needle shield in the retracted position when the injection device is its 'zero' position such that a user has access to the injection needle in order to exchange the injection needle.

Shield lock for spring driven injection device

A medical device is provided comprising a transcutaneous device unit and a process unit. The transcutaneous device unit may comprise a transcutaneous device for transporting a fluid through a skin portion of a subject, and a mounting surface adapted for application to the skin of the subject. The process unit may comprise a reservoir adapted to contain a fluid drug, the reservoir comprising an outlet means allowing the transcutaneous device to be arranged in fluid communication with an interior of the reservoir, and an expelling assembly for expelling a fluid drug out of the reservoir and through the skin of the subject via the transcutaneous device. The transcutaneous device unit and the process unit further comprise coupling means allowing the reservoir unit to be secured to the transcutaneous device unit in the situation of use. By this arrangement a two-unit system is provided which can be used in a convenient and cost-effective manner.

Medical skin mountable device and system

An injection device comprising a housing and a dose setting mechanism including a dose setting element. Contrary to prior art injection devices, the dose setting element can only be set at a few different dose settings. This is established by forming the dose setting element as a rotatable dish concealed within the housing and having a number of projections projecting outside the boundaries of the housing through a slot in the housing. A dose is set by activating a projection which in addition provides the user with a tactile guidance. Usually one projection is provided for one dose setting limiting the number of doses to be set to the number of projections.

Injection device with rotatable dose setting

The present invention provides an injection syringe comprises a housing including a holder for containing a cartridge of medicine, a piston rod with a non-circular cross-section having an outer thread, a piston rod drive, a one way coupling having an annular ring of internal ratchet notches, which annular ring can be integral with the housing, and a pawl having at least a pair of resilient arms each having a free end.

Injection syringe

The invention provides a pump assembly comprising an actuator lever, a supporting structure, a pump comprising a pump member moveable by actuation of the actuator lever, and an actuator for moving the actuator lever. A first stationary pivoting joint is formed between the actuator lever and the supporting structure, and a second floating pivoting joint is formed between the actuator lever and the pump member allowing the pump member to float relative to the actuator lever, the floating pivoting point providing a constant-length actuator arm defined between the first pivoting joint and the second pivoting joint.

Actuator system comprising lever mechanism

A limiting mechanism which prevents the setting of a dose, which exceeds the amount of liquid left in a cartridge of an injection device, is disclosed. The injection device is the type where a dose is set by rotating a dose setting member relative to a driver and away from a fixed stop in the injection device. The dose setting member interfaces the driver such that the dose setting member can be rotated in one direction without rotating the driver. The dose is injected by rotating back the dose setting member which during the backward rotation carries the driver with it. Rotating the driver causes the piston rod to move forward inside the cartridge and expel some of the liquid contained in the cartridge. The driver is provided with a track having a length which is related to the total amount of liquid in the cartridge and which track is engaged by a track follower coupled to the dose setting member to follow rotation of this dose setting member. Each time a dose is set and injected, the track follower moves further into the track. When the track follower reaches the end of the track the dose setting member can not be rotated further, and a dose larger than the remaining liquid in the cartridge cannot be set.

Dose setting limiter

An end-of-content arrangement for preventing a dose setting member of an injection device to be set to a dose larger that the medicament remaining in the injection device. The arrangement is particular suitable for injection devices operating with non-equistant dose volumes. The arrangement comprises an indentation provided on the housing or on the dose setting and injection member which indentation arrest a stop member when less than one dose unit is left in the cartridge. The stop member is coupled to the dose setting member such that the interaction between the indentation and the stop member prevents a dose larger that the remaining medication in being set.

Injection device with a dose setting limiter

The invention relates to membrane pumps for delivering liquids. More specifically, a pump is provided having a pump housing with a pump cavity formed between first and second wall portions thereof, and an pump membrane pump membrane having first and second membrane surfaces arranged within the pump cavity, whereby a pump chamber is provided between the first wall portion and the first membrane surface, and an actuation chamber is provided between the second wall and the second membrane surface. Inlet means comprising an inlet valve in fluid communication with the pump chamber, and outlet means comprising an outlet valve in fluid communication with the pump chamber are provided. The pump membrane has a maximum volume position, and a drained volume position in which the first membrane surface in a stretched state abuts the first wall. To drive the membrane, actuating means for periodically shifting the pump membrane between the maximum volume position and the drained volume position is provided, thereby, in a situation of use, providing a flow of fluid.

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Hilleroed, Denmark

Steffen Hansen