Novozymes A/s

Kerry Group Services International Limited

Chr. Hansen A/s

Steffen Ernst

Hanne Vang Hendriksen

Jeppe Wegener Tams

Reinhard Wilting

Helle Skov Guldager

Mette Oerhrstroem Runge

Martin Schulein

Arne Agerlin Olsen

Lars Kongsbak

Henri Chanzy

William Helbert

Tommy Lykke Husum

Kim Vilbour Andersen

Lisbeth Kalum

Peter Rahbek Oestergaard

Per Munk Nielsen

Claus Von Der Osten

Gitte Budolfsen Lynglev

Erwin Ludo Roggen

Erwin Lugo Roggen

Martin Barfoed

Hanne Vang Henriksen

The present invention relates to a method for producing a dairy product using an enzyme having lactase activity.

Method for producing a dairy product

The present invention relates to a method for extracting components from yeast cells with a purified phospholipase.

Method for extracting components from a yeast cell culture

The present invention relates to an enzymatic process for making a milk-based protein hydrolysate and use of such hydrolysate, e.g., in an infant formula composition.

Process for making a milk-based protein hydrolysate

The present invention relates to a method of selecting a protein variant having reduced immunogenicity as compared with the parent protein. This method includes the steps of screening a random peptide display package library with antibodies raised against any protein of interest, sequencing the amino acid sequence of the antibody binding peptides, or the DNA sequence encoding the antibody binding peptides, identifying epitope patterns of a protein by sequence alignment of the reactive peptide sequence, localization of epitope patterns on the primary 3-dimensional structure of the parent protein, defining an epitope area including amino acids situated within 5 &angst; from the epitope amino acids, and affecting antibody binding to the epitope, changing the localized epitope patterns, or amino acids defining the epitope area of the parent protein by genetic engineering mutations of a DNA sequence encoding the parent protein without impairing functionality of the protein using the emerging epitode database for eliminating amino acid substitutions creating new or duplicating existing epitope patterns, introducing the mutated DNA sequence into a suitable host, culturing the host and expressing the protein variant, and evaluating the immunogenicity of the protein variant using the parent protein as reference. The invention further relates to the protein variant and its use, as well as to a method for producing said protein variant.

Low allergenic protein variants

The invention relates to a ellulose film comprising microfibrillated cellulose and to the use of it for screening of a biological compound and nucleic acids encoding a biological compound.

Cellulose films for screening

The present invention relates to polypeptides with reduced immune response including reduced allergenicity having one or more amino acid residues being substituted with other amino acid residues and/or having coupled one or more polymeric molecules in the vicinity of the polypeptides metal binding site, a method for preparing modified polypeptides of the invention, the use of the polypeptide for reducing the immunogenicity and allergenicity and compositions comprising the polypeptide.

Modified polypeptide

The invention relates to a cellulose film comprising microfibrillated cellulose and to the use of it for screening of a biological compound and nucleic acids encoding a biological compound.

Growing community of inventors

Broenshoej, Denmark

Steffen Ernst