Alliedsignal Inc.

Alfa Wassermann S.p.a.

P.f.c. Italiana S.r.l.

Stefano Saguatti

Vincenzo Cannata

Valeriano Merli

Goffredo Rosini

Silvano Piani

Claudia Baldazzi

Eleonora Romagnoli

Process for the production of alkoxycarbonyldipeptides intermediates in the synthesis of the lisinopril which comprises protecting both amino functions of the L-lysine with an alkoxycarbonyl group, subsequently making the N-carboxyanhydride of the N6-[alkoxycarbonyl]-L-lysine by treatment with thionyl chloride and making the desired alkoxycarbonyldipeptide by reaction with L-proline in alkaline medium.

Process for the production of alkoxycarbonyldipeptides intermediates in

Process for the production of alkoxycarbonyl-dipeptides intermediates in

Lactones of formula ##STR1## and their pharmacologically acceptable salts endowed with antioxiding and hypolipidaemic properties and that show the capability to prevent and/or to delay the oxidative modification of the lipoproteins by competing with the chain of propagation of the lipidic peroxidation by means of an effective scavenging of the peroxylic radicals. The compounds object of the present invention are useful in the treatment of the atherosclerosis and of many correlated vascular pathologies, like ischaemic cardiopathies (angina pectoris and myocardial infarction), cerebral thrombosis and peripheral arteriopathies, because the high plasma levels of lipids and the oxidative modifications of the low density lipoproteins (LDL) represent crucial events in the pathogenesis of the atherosclerosis.

Lactones with antioxidising and hypolipidaemic activity useful in the

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Bologna, Italy

Stefano Saguatti