Sorin Biomedica Cardio S.p.a.

Sorin Biomedica S.p.a.

Dideco S.p.a.

Consiglio Nazionale Delle Ricerche

Ministero Dell'universita E Della Ricerca Scientifica E Tecnologica

Stefano Rinaldi

Franco Vallana

Enrico Pasquino

Maria Curcio

Leopoldo Della Ciana

Gioachino Bona

Arnaldo Giannetti

Giampiero Porro

Massimo Earl Fini

Carla Stacchino

Giuseppe Caputo

Pietro Arru

Andrea Grignani

Marco Santi

Fabio Inzoli

Maurizio Zagara

Mauro Ercolani

Franco Montevecchi

Giampero Porro

Silvio Sacco

Maurizio Arabia

Silvia Pascale

Francesca Licci

Giorgio Sorcini

Tullo Besagni

Manlio Fierli

A prosthesis having an apertured structure is located in a chamber ( ) which is taken to sub-atmospheric pressure. Once sub-atmospheric pressure has been reached, a liquid, optionally containing pharmacological agents, is introduced into the chamber. Drawn by the sub-atmospheric pressure, the liquid saturates the apertured structure of the prosthesis. In this way, the invention eliminates the risk of air being trapped in the apertured structure that could give rise to the formation of blood clots after implantation of the prosthesis. The liquid can contain drugs that penetrate the prosthesis, performing their therapeutic action locally and over time after implantation.

Method for treating a prosthesis having an apertured structure and associated devices

A device comprises a bag with associated actuator means which can be selectively activated to permit the expansion of the bag and its consequent filing with a body of blood which flows towards the bag, and to produce the contraction of the bag with the consequent expulsion from the bag of a body of blood which has flowed into the bag. Means are provided for selectively varying the resistance offered by the said bag to filing with the said body of blood.

Ventricular assist device, accessory therefore and method of use

A method for reducing foam in a blood substance comprising contacting at least a portion of the blood substance with a contact-generating substrate which comprises an antifoaming agent, wherein the antifoaming agent comprises a triglyceride of one or more saturated or unsaturated C.sub.14 -C.sub.24 fatty acids or a mixture of triglycerides having one or more saturated or unsaturated C.sub.14 -C.sub.24 fatty acids, wherein the triglyceride or mixture of triglycerides has a hydrophilic-lipophilic balance of from 5 to 10.

Method for reducing foam in a blood substance and antifoaming agents

A method of preparing biological implantation material fixed by means of aldehydes, in which the excess aldehyde is bound by treatment with an aminocarboxylic acid and the acid is selected from compounds of the general formula: ##STR1## in which n is 1 or 2 and X is a sulpho- (--SO.sub.3 H) or phosphono- (--PO.sub.3 H) group, and mixtures of such compounds.

Method of preparing biological implantation material

Physico-chemical parameters, such as pH, pO.sub.2, pCO.sub.2, % O.sub.2, sat, etc., are determined with the use of a sensitive medium, such as a chromophore, having at least one optical property the profile of the spectrum whereof over a predetermined wavelength spectrum of optical radiation varies as a function of the parameter to be determined. The profile of the spectrum is analysed, for example by means of polychromatic sensor means acting on the medium's spectrum, which is preferably substantially continuous, so as to enable the analysis to be carried out with the aid of a profile-recognition function by typical pattern-recognition operations. The determination is thus rendered largely independent of numerous perturbing factors such as those resulting from the use of partially disposable monitoring units, thus eliminating the need for calibration steps.

Method and equipment for detecting physico-chemical parameters

The structure has a core which may be a strand or braid, as well as a sheath surrounding the core and defining the exchange surface. Preferred applications are for biomedical equipment such as blood oxygenators and blood purification equipment.

Exchange structure for biomedical equipment

A device for the pulsed pumping of liquids, particularly blood, has a body in which are formed a pumping chamber in which a pulsed flow is imparted to the liquid, an inlet duct upstream of the pumping chamber and communicating therewith, and a delivery duct downstream of the pumping chamber and communicating therewith. Two valve members constituted by lip valves are provided for regulating the one-way flow of fluid in the body from the inlet duct to the pumping chamber and from the latter to the delivery duct. Low levels of hemolysis can be achieved, if the device is pumping blood. Moreover, the device has a low production cost and is quiet. The pumping device may be incorporated into a cardiopulmonary bypass device which includes a venous reservoir, a heat exchanger and an oxygenator.

Device for the pulsed pumping of liquids, particularly blood

A stentless prosthesis is made completely from material, for example bovine pericardium, other than valve material. A projection of the valve sleeve allows reparatory operations on surrounding tissues.

Cardiac valve prosthesis particularly for replacement of the aortic valve

There are disclosed devices for conditioning a blood flow which include at least one element with portions which are exposed to the blood and are deformable cyclically at a frequency comparable to the frequency of the heartbeat, in which the cyclically deformable portions have a continuous coating of biocompatible carbonaceous material comprised of carbon crystals having a density of greater than 2.1 grams per cubic centimeter applied by sputtering directly on and completely covering at least those portions of the device which are exposed to the blood.

Cyclically deformable haemocompatible and biocompatible devices coated

A heart valve prosthesis has a suture ring with a core for form-coupling with the stent of the prosthesis so that the suture ring and the stent are held securely together axially, while the core can rotate relative to the stent. The suture ring has a covering which cooperates with the surface of the stent and is in contact therewith. The degree of contact determines the resistance to relative rotation of the ring and the stent.

Heart valve prosthesis

The thickness of the obturator (3) increases gradually from the central region (C.sub.9 C.sub.10) towards the ends (P.sub.9, P.sub.10) of the edge (6) nearest to the axis of articulation (5) to the prosthesis, and decreases gradually or is constant from that edge to the other end edge (7) which forms the outer edge of the obturator.

Obturator for heart valve prostheses, a heart valve prosthesis provided

In a prosthetic heart valve comprising a generally annular stent and at least two obturators mounted in the stent so as to be above to pivot between an open position and a closed position, the stent is provided with at least one element which projects inwardly of the stent itself, while each of the obturators has recesses which cooperate with the projecting element of the stent with clearance in a generally-hinged configuration which enables the obturators to pivot between the open position and the closed position.

Prosthetic heart valve

The method disclosed by which to prepare fine hexagonal ferrites for use in magnetic recording, is one which consists basically in dissolving (a) carbonates or other soluble compounds of an alkaline earth metal such as strontium or barium, (b) a carbonate or other soluble compound of cobalt, and (c) titanium trichloride, all in a solution of ferric citrate and water, whereupon a polycondensation is brought about by addition of ethylene clycol, and heat is applied to eliminate the water and organic matter from the compound. Addition of the alkaline earth metal, the cobalt and the titanium is proportioned precisely on the basis of the stoichimetric properties of the end-product, the formula for which is

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Parma, Italy

Stefano Rinaldi