Poli Industria Chimica Spa

Polichem S.a.

Roli Industria Chimica S.p.a.

Stefano Poli

Germano Coppi

Lucio Del Corona

Luigi Moro

Ambrogio Magni

Federico Mailland

Paride Grisenti

Cesare Busetti

Tiziano Crimella

Giovanni Signorelli

Roberto Girardello

Vincenzo Olgiati

Diastereomerically pure 3-oxo and 3-thioxo-4-aza-androstan derivatives

The invention relates to pharmaceutical compositions for parenteral administration. The compositions comprise an amount of neuromuscular blocking agent effective to produce muscular relaxation, and at least one zwitterionic substance having an isoionic point not greater than 7. The zwitterionic substance is present in an amount of between about 2 and about 30 percent by weight, based on the weight of the composition. The resulting composition has a pH of less than 7.

Muscle relaxant pharmaceutical compositions

Bioadhesive microemulsions or liposomic dispersions containing proteinaceous substances, especially calcitonin, that allow the systemic, local or topical administration of drugs by transmucosal route are described. This type of administration shows some considerable advantages of activity, tolerability, dosage individualization and drug stability.

Microemulsion pharmaceutical compositions for the delivery of

Liquid bioadhesive microemulsions or liposomic dispersions containing proteinic substances, especially calcitonin, that allow the systemic, local or topical administration of drugs by transmucosal route are described. This type of administration shows some considerable advantages of activity, tolerability, dosage individualization and drug stability. The compositions contain proteinic substances, and a polyoxyethylene-polyoxypropylene thermosetting copolymer. At body temperature the viscosity of the compositions is increased and provides increase residence time at the administration site.

Pharmaceutical compositions for transmucosal delivery of peptides

A liquid pharmaceutical composition which can be administered as a foam by means of suitable supplying devices, without necessity of gas propeller, said composition consisting of:

Oral, cutaneous and intravaginal pharmaceutical compositions in the form

N-(5-thioxo-L-prolyl)-L-cysteine and derivatives thereof, having interesting mucolytic-expectorant, antioxidant (radical-scavenger), antielastase, antiemphysema, immunostimulating and hepatoprotective activities and a low toxicity are described, as well as processes for the preparation thereof and pharmaceutical formulations for the use in therapy.

N-(5-thioxo-L-prolyl)-L-cysteine, derivatives thereof, processes for the

3-L-(5-thioxo-L-prolyl)thiazolidine-4-carboxylic acid and the derivatives thereof have valuable immunostimulating, antioxidant, antiradical and antiageing properties. They are prepared by thionating the corresponding 3-L-pyroglutamyl-L-thiazolidine-4-carboxylic acid derivatives or by condensing 5-thioxo-L-proline with the corresponding L-thiazolidine-4-carboxylic acid derivatives.

3-L-(5-thioxo-L-prolyl)thiazolidine-4-carboxylic acid and derivatives

3-(L-pyroglutamyl)-L-thiazolidine-4-carboxylic acid and derivatives thereof are prepared by condensing L-pyroglutamic acid or its substitution products, either in the presence of dicyclohexylcarbodiimmide or the like, or by condensation of active derivatives of L-pyroglutamic acid with 4-thiazolidine-carboxylic acid derivatives.

Process for the preparation of

Ester or amide derivatives of 3-pyroglutamylthiazolidine-4-carboxylic acid exhibit interesting immunostimulating, antitoxic, antiinflammatory, antioxidental, antiageing properties.

Derivatives of thiazolidine-4-carboxylic acid, its preparation and

New N-(2-cycloalkylamino)ethyl-substituted benzamides having a powerful stimulating activity on gastric motility and with a low central anti-dopaminergic activity are described. The synthesis and the pharmaceutical preparation for therapeutical use are also described.

N-cycloalkylaminoethylbenzamide derivatives, their synthesis and

3-L-pyroglutamoyl-thiazolidine-4-carboxylic acid, prepared starting from an activated ester of L-pyroglutamic acid from pyroglutamoyl chloride and L-thiazolidine-4-carboxylic acid, exhibits interesting immunostimulant, antitoxic, antiinflammatory, antioxidant and anti-aging properties.

Derivative of thiazolidine-4-carboxylic acid, its preparation and

A pharmaceutical composition containing .alpha.-dihydroergocryptine, or a salt thereof, is used in combination with pharmaceutically acceptable carrier means or excipient for the treatment of Parkinson's disease, depression or cephalalgias is disclosed. A method for administering the composition to a patient is also provided.

Growing community of inventors

Milan, Italy

Stefano Poli