4sc Ag

Stefano Pegoraro

Kristina Wolf

Johann Leban

Harald Schmitt

Andreas Wuzik

Wael Saeb

Bernd Kramer

Juergen Kraus

Rolf Krauss

Martin Lang

Johan Leban

Gabriel Garcia

Andrea Aschenbrenner

Matthias Dormeyer

Andreas Wuzík

Jürgen Kraus

Juliane Feurle

Katharina Aulinger Fuchs

The present invention relates to novel sulfamoyl-phenyl-ureido compounds having the formula (I) or a physiologically acceptable salt or derivative thereof which are suitable for the therapy of infections caused by protozoa and in particular uncomplicated or severe malaria caused by plasmodia. 

Sulfamoyl-phenyl-ureido compounds and their use as medicament

The present invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, (I) wherein Ris independently hydrogen, alkyl, cycloalkyl, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl or substituted arylalkyl; Ris independently &#x2014;NRR, (II) or (III) Ris independently alkyl, cycloalkyl, alkoxy, alkylamine, &#x2014;OH, &#x2014;SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl, Ris independently alkyl, cycloalkyl, alkoxy, alkylamine, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl; Ris independently H, COR, COR, SOR, SOR, SOR, alkyl, cycloalkyl, alkoxy, &#x2014;NH, alkylamine, &#x2014;NRCOR, halogen, &#x2014;OH, &#x2014;SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl; Ris independently H, alkyl, cycloalkyl, &#x2014;NH, alkylamine, aryl or heteroaryl; Ris independently H, alkyl, cycloalkyl, alkoxy, &#x2014;OH, &#x2014;SH, alkylthio, hydroxyalkyl, aryl, or heteroaryl; p is 0, or 1; q is 0, or 1; X is CO, or SO. 

Heterocyclic NF-&#x3ba;B inhibitors

The present invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, wherein 

The present invention relates to compounds of the general formula (III) or pharmaceutically acceptable salts thereof with an acid or a base, or pharmaceutically acceptable prodrugs or a stereoisomer thereof, 

Heterocyclic NF-kB inhibitors

The present invention relates to compounds of the general formula (IV) and (II) and salts and physiologically functional derivatives thereof,  

Phenantridine analogues and uses thereof

The invention relates to new diphenylurea having the formula (I)or a salt thereof, where

Compounds for the treatment of protozoal diseases

Growing community of inventors

Planegg, Germany

Stefano Pegoraro