Laboratorio Chimico Internazionale S.p.a.

Olon S.p.a.

Mediolanum Farmaceutici

Mediolanum Farmaceutici, S.r.l.

Biontech Ag

Consiglio Nazionale Delle Ricerche

Agip Petroli

Schiapparelli Farmaceutici S.p.a.

Mediolanum Farmaceutici S.r.l. Consiglio Nazionale Delle Ricerch

Labochim Laboratorio Chimico Internazionale S.p.a.

Universita′ Degli Studi Di Milano

Fondazione Irccs Istituto Nazionale Dei Tumori

Fondazione Cariplo

Cisi Scrl

Stefano Maiorana

Pier G Pagella

Mario Brufani

Giorgio Bertolini

Mara Sada

Federica Colombo

Corrado Colli

Aldo Bianchi

Patrizia Terni

Enrico Ferrari

Filippo Nisic

Antonio Nardi

Annibale Salvi

Sperandina Lappa

Giorgio Chiodini

Maria C Cesta

Donata Marchesini

Maria Alessandra Alisi

Silvano Ronzoni

Piergiuseppe Pagella

Leonardo Manzoni

Pierfausto Seneci

Eloise Mastrangelo

Pier L Rugarli

Mario Milani De Mayo De Mari

Luigi Filocamo

Antonio Papagni

Laura Belvisi

Domenico Delia

Carmelo Drago

Francesca Vasile

Paola Maria Chiara Perego

Paolo Maria Farina

Romano Di Fabio

Gabriele Timpano

Gianluca Gostoli

Federica Cossu

Aldo Belli

Stefania Bertuolo

Daniele Lecis

Paolo Biagini

Paolo Koch

Roberto Fusco

Francesco Corcella

Lazzaro Feliciani

Federico Gassa

Faris Garis

Massimo Pomponi

Raffaello Fusco

Piero Dalla Croce

Clara Baldoli

Cinzia Biaggi

Adolfo Prandi

Paolangelo Cerea

Renè Ignacio Rodriguez Curiel

Emanuela Licandro

Carlo Meroni

René Ignacio Rodriguez Curiel

Riccardo Bernardi

Alessandro Agosti

Gabriella Brandi

Luigi Eieocamo

Anna Bonura

Giacomina Mandelli

Lucia Mairani

Diego G Brocchetti

Giuseppe Piacenza

Leonardo Pierpaolo Manzoni

Subject-matter of the present invention is a process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction of the corresponding beta-amino ketones. Subject-matter of the invention are also said novel synthesis intermediates and the use thereof in the preparation of active pharmaceutical ingredients, among which vilanterol and the salts thereof.

Process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction and novel synthesis intermediates

The present invention relates to a process for the preparation of a novel and versatile synthesis intermediate and its use in the preparation of umeclidinium. The invention also relates to some reference standards allowing to detect impurity traces recurring in the preparation of umeclidinium and a process for their preparation.

Process for the preparation of a novel umeclidinium synthesis intermediate

Subject-matter of the invention is a process for the preparation of key intermediates in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates.

Process for the preparation of indanamine derivatives and new synthesis intermediates

Subject-matter of the invention is a process for the preparation of a key intermediate in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates. Formula (I): 

The present invention refers to a process for the preparation of 1-(2-halogen-ethyl)-4-piperidinecarboxylic acid ethyl esters, in particular of 1-(2-chloroethyl)-4 piperidinecarboxylic acid ethyl ester, a versatile synthesis intermediate, particularly useful as an intermediate compound in the synthesis of umeclidinium.

Method for the preparation of 1-(2-halogen-ethyl)-4 piperidine-carboxylic acid ethyl esters

The present invention refers to a new process for preparing levomilnacipran, in particular to a process for the resolution of racemic tw-milnacipran with a derivative of optically active phenylglycine.

Process for preparing levomilnacipran

The present invention relates to conformationally constrained homo- and heterodimeric mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.

Homo- and heterodimeric SMAC mimetic compounds as apoptosis inducers

The present invention refers to a new 'one-pot' process for the preparation of olopatadine via intermediates of formula (III). 

Process for the preparation of olopatadine and sylil intermediates thereof

Compound comprising a benzoetherodiazole group of formula (I) and at least one benzodithiophene group or a mixture of compounds comprising a benzoetherodiazole group and at least one benzodithiophene group of formulae (II) and (III). Both said compound and said mixture of compounds can be advantageously used as spectrum converters in luminescent solar concentrators (LSCs), capable, in their turn, of enhancing the performances of solar devices (i.e. devices for exploiting solar energy) such as, for example, photovoltaic cells, photoelectrolytic cells.

Benzodithiophene derivatives and their use as photoluminescent compounds

The invention relates to a new process for the preparation of dronedarone and its salts, in particular a synthesis process which allows said compound and its salts to be obtained with good yields, high purity and in an industrially expedient manner; the invention also concerns a new synthesis intermediate.

Process for the manufacture of dronedarone

The invention concerns a new process for the preparation of high purity diacerein, by oxidization of the protected aloe-emodin in the presence of an oxidizing system and radical catalyst and subsequent substitution of the protector groups with acetyl groups.

Process for the preparation of DIACEREIN

The invention concerns a new process for the preparation of naphthoquinones, in particular an improved process for the preparation of 2,3-disubstituted 1,4-naphthoquinones, in the trans configuration.

Process for the preparation of trans-2,3-disubstituted naphthoquinones

Process for the synthesis of racemic thioctic acid comprising the following stages: a) reaction of the alkyl ester of 6,8-di-halo-octanoic acid in an organic solvent with an aqueous solution of alkali disulfide in presence of a compound for phase transfer catalysis selected from the group consisting of quaternary ammonium or phosphonium salts having the following general formula: where: A is nitrogen of phosphorus, X is selected from the group consisting of Cl, Br, I, HSO, and HPOand the substitutents R, R, Rand Rare selection from the group consisting of linear or branched alkyl radicals having one to twenty carbon atoms (C1-C20), said substituents being identical or different one from the other, or only one of said substituents is selected from the group consisting of arylalkyl radicals having the following formula &#x2014;(CH)CHin which n=1-16; b) followed by the hydrolysis of the ester of racemic thiotic acid.

Process for the production of a racemic thioctic acid

Phenylcarbamate derivatives suitable to the use as anticholinesterase

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Stefano Maiorana