University of Minnesota

Princeton University

UniversitÀ Di Napoli “Federico Ii” Dipartimento Di Ingegneria Chimica, Dei Materiali E Della Produzione Industriale

Stefano Guido

Robert T Tranquillo

Daniel L Mooradian

Timothy Samuel Girton

Howard A Stone

Janine K Nunes

Antonio Perazzo

Timothy Sanuel Girton

Provided is a hydrogel. The hydrogel includes a liquid and a plurality of microfibers suspended in the liquid as an entangled network. The entangled network includes physically entangled microfibers that are mechanically interlocked.

Injectable hydrogels from microfiber suspensions

Tissue-equivalent and biopolymer tubes and rods include fibrils which are oriented (aligned) by a magnetic field. These oriented fibrils provide enhanced mechanical and cell guidance properties to the tissue-equivalent and biopolymer tubes. One such tissue-equivalent tube includes a body of collagen gel with mammalian tissue cells interspersed therein. The collagen fibrils are circumferentially oriented within the tubular body by a magnetic field, thereby inducing circumferential orientation of the cells. One such biopolymer rod includes collagen fibrils longitudinally oriented along the rod axis by a magnetic field that guides invasion of cells. Methods of making magnetically oriented tissue-equivalent and biopolymer tubes and rods are also disclosed.

Magnetically oriented tissue-equivalent and biopolymer tubes and rods

Method of nerve regeneration using biopolymer rods with oriented fibrils

Tissue-equivalent and biopolymer tubes include fibrils which are oriented by a magnetic field. These oriented fibrils provide enhanced mechanical properties to the tissue-equivalent and biopolymer tubes. One such tissue-equivalent tube includes a body of collagen with mammalian tissue cells interspersed therein. The collagen fibrils are circumferentially oriented within the tubular body by a magnetic field, thereby inducing circumferential orientation of the cells. Methods of making magnetically oriented tissue-equivalent tubes and biopolymer tubes are also disclosed.

Magnetically oriented tissue-equivalent and biopolymer tubes

Tissue-equivalent rods containing aligned collagen fibrils and schwann

Growing community of inventors

Naples, Italy

Stefano Guido