F.i.s. Fabbrica Italiana Sintetici S.p.a.

Other

F.i.s.-fabbrica Italiana Sintetiei S.p.a.

Stefano Fogal

Riccardo Motterle

Marco Galvagni

Ottorino De Lucchi

Andrea Castellin

Stefano Tartaggia

Clark Ferrari

Alex Comely

Marta Pontini

Giancarlo Arvotti

Elisabetta Bergantino

Rosa Maria Moreno

Pierluigi Padovan

Paolo Stabile

Angelo Restelli

Alfredo Paio

Matteo De Poli

Mattia Niero

Marina Simona Robescu

The present invention relates to a process for the preparation of Droxidopa by means of an improved enzymatic reduction of a compound of formula (II): (II), wherein R, Ris independent hydrogen, acetyl, Ris hydrogen, a C1-C4 linear or branched alkyl group and Ris hydrogen or an amine protecting group. 

Enzymatic process for the preparation of Droxidopa

The present invention relates to a new process for the preparation of testosterone by means of enzymatic hydrolysis of testosterone esters.

Enzymatic process for the preparation of testosterone and esters thereof

Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of statins.

Convenient process for the preparation of statins

The present invention relates to the stereoselective synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine, as well as the conversion thereof, to give Moxifloxacin. Particularly, the present invention relates to a method for the synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine of formula (I) comprising: (a) the optical resolution by enzymatic hydrolysis of the intermediate dialkyl-1-alkylcarbonylpiperidine-2,3-dicarboxylate racemate of formula (II) to give, following isolation, the intermediate dialkyl-(2S,3R)-1-alkylcarbonyl-piperidine-2,3-dicarboxylate of formula (III) in which AIk is a straight or branched C1-C5 alkyl group; (b) the conversion of the intermediate (III) to (4aR,7aS)-1-alkylcarbonylhexahydrofuro[3,4-b]pyridine-5,7-dione of formula (IV) in which AIk has the meanings set forth above; (c) the conversion of the intermediate (IV) to (4aS,7as)-octahydro-1H-pyrrolo[3,4-b]pyridine of formula (I) with an optical purity above 99%. 

Synthesis of (4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridine

The present invention relates to an industrial process for the reduction of 4-androstene-3,17-dione in order to obtain testosterone using a particularly stable and selective enzyme produced in a recombinant manner.

Process for the preparation of testosterone

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Brendola, Italy

Stefano Fogal