Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Institut Pasteur

Miltenyi Biotec, Gmbh

Xentech

Stefano Cairo

Olaf Hardt

Aurélien De Reynies

Marie-Annick Buendia

Carolina Armengol Niell

Evgeniya Petrova

Jean-Gabriel Judde

Olivier Deas

Aurelien De Reynies

Andeas Bosio

Andrea Aloia

The present invention concerns a method to determine the gene expression profile on a sample previously obtained from a patient diagnosed for a liver tumor, comprising assaying the expression of a set of genes in this sample and determining the gene expression profile (signature). In a particular embodiment, said method enables to determine the grade of the liver tumor, such as hepatoblastoma (HB) or a hepatocellular carcinoma (HCC). The invention is also directed to kits comprising a plurality of pairs of primers or a plurality of probes specific for a set of genes, as well as to solid support or composition comprising a set of probes specific for a set of genes. These methods are useful to determine the grade of a liver tumor in a sample obtained from a patient, to determine the risk of developing metastasis and/or to define the therapeutic regimen to apply to a patient.

Molecular signature of liver tumor grade and use to evaluate prognosis and therapeutic regimen

Growing community of inventors

Longpont-sur-Orge, France

Stefano Cairo