Glaxo Group Limited

Glaxosmithkline LLC

Glaxo Inc.

Glaxo Wellcome Spa

Via Pharmaceuticals, Inc.

Pliva D.d.

Stefano Biondi

Daniele Andreotti

Tino Rossi

Giovanni Gaviraghi

Sergio Lociuro

Gorjana Lazarevski

Luca Tarsi

Alcide Perboni

Giovanna Tedesco

Cesare Mondadori

Antun Hutinec

Jessica Tibasco

Miljenko Dumic

Drazen Pavlovic

Daniele Donati

Stjepan Mutak

Domenica Antonia Pizzi

Aldo Feriani

Zorica Marusic-Istuk

Federica Damiani

Emiliangelo Ratti

Claudio Bismara

Ilaria Bientinesi

Gabriella Finizia

Marko Djerek

Bruno Tamburini

Andrea Berdik

Suleman Alihodzic

Alfredo Paio

Vlado Stimac

Russell John Thomas

Stefania Anna Contini

Wolfgang Schoenfeld

Anna Quaglia

Vesna Erakovic

Manuela Ciraco

Patrick Wagner

Emmanuelle Limanton

Jérôme Duranton

Mustapha Abarghaz

The invention relates to compounds having PDE2 inhibitory activities, as well as therapeutic methods by administering said compounds, in particular for treating various diseases of the central or peripheral nervous system. It further deals with pharmaceutical compositions comprising said compounds and methods for preparing said compounds.

Benzo-1,4-diazepin-2-one derivatives as phosphodiesterase PDE2 inhibitors, preparation and therapeutic use thereof

The present invention relates to 14 or 15 membered macrolides substituted at the 4' position of formula (I) and pharmaceutically acceptable salts and solvates thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical bacterial infections in a human or animal body 

Macrolides

11,12 &#x3b3; lactone ketolides of the following formula:and pharmaceutically acceptable salts and solvates thereof, wherein R, R, R, and Rare as described herein. The disclosure also relates to processes for the preparation of such compounds, to compositions containing them, and to their use in the therapy or prophylaxis of systemic or topical bacterial infections in a human or animal body.

Macrolide antibiotics

A compound of formula (I), salts and metabolically labile esters thereof, wherein R represents optionally substituted aryl or heteroaryl group; A represents a propylene chain or A is a chain of members one of which is selected from an oxygen or sulphur atom or the group NH or a substituted derivative thereof and the other two members are methylene groups, having antibacterial activity, processes for their preparation and to their use in medicine.

Tricyclic carbapenem compounds

Compounds of the formula ##STR1## wherein R.sub.1 represents hydrogen or a nitrogen protecting group, useful as intermediates in the preparation of compounds having antibacterial activity.

Cyclohexene derivatives

Compounds of the general formula (I) ##STR1## in which: R.sub.1 represents a hydroxyl protecting group; and

4-(2-Oxo-cyclohexyl) azetidinones

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Verona, Italy

Stefano Biondi