California Institute of Technology

Slipchip Corporation

Etat Francais Represented by Ministere De La Defense

Sorbonne Universite, Centre National De La Recherche Scientifique

Centre National De La Recherche Scientifique

Sorbonne Université

Talis Biomedical Corporation

Etat Français Représenté Par Le Ministère De La Défense

Stefano Begolo

Rustem F Ismagilov

David A Selck

Mikhail Karymov

Jean-Louis Viovy

Feng Shen

Laurent Malaquin

Erik B Jue

Stephanie Descroix

Philip Homewood

Liang Li

Yu-Hsiang Hsu

Anais Ali Cherif

Philip James Homewood

Stephanie McCalla

Dmitriy V Zhukov

Qichao Pan

Jesus Rodriguez Manzano

Anaïs Ali Cherif

The present invention relates to methods, computer readable medium and systems for detecting and counting single nucleic acid molecules confined in nanoliter volumes using an unmodified camera, such as a cell phone camera. In particular, it identifies colorimetric amplification-indicator dyes that are compatible with the spectral sensitivity of standard mobile phones. The invention further provides an optimal ratiometric image-process for a selected dye to achieve a readout that is robust to lighting conditions and camera hardware and provides unambiguous quantitative results, even for colorblind users.

Devices and methods for direct visual detection and readout of single nucleic acid molecules

The present invention concerns a microfluidic system comprising: a microchannel containing several elements of two non-miscible fluids, the microchannel comprising a droplet () containing magnetic particles (M), and a device for generating inside the microchannel magnetic field, said device comprising an activable magnetic element, the activable magnetic element comprising a tip (), the microfluidic system being configured to transport the droplet by flow or by pressure difference.

Microfluidic system

The present invention relates to fluidic devices for preparing, processing, storing, preserving, and/or analyzing samples. In particular, the devices and related systems and methods allow for preparing and/or analyzing samples (e.g., biospecimen samples) by using one or more of capture regions and/or automated analysis.

Fluidic devices and systems for sample preparation or autonomous analysis

The present invention relates to fluidic devices for preparing, processing, storing, preserving, and/or analyzing samples. In particular, the devices and related systems and methods allow for preservation or storage of samples (e.g., biospecimen samples) by using one or more of a bridge, a membrane, and/or a desiccant.

Fluidic devices for biospecimen preservation

Growing community of inventors

Pasadena, CA, United States of America

Stefano Begolo