Basf Se Corporation

Stefanie Kind

Christoph Wittmann

Judith Becker

Recombinant microorganisms comprising DNA molecules in a deregulated form which improve the production of cadaverine or N-acetylcadaverine, as well as recombinant DNA molecules and polypeptides used to produce the microorganisms are provided. Said microorganisms comprise an intracellular lysine decarboxylase activity and a deregulated cadaverine export activity, or comprise a decreased cadaverine export activity and an enhanced N-acetylcadaverine forming activity. Processes for the production of cadaverine N-acetylcadaverine using the recombinant microorganisms are also provided.

Processes and recombinant microorganisms for the production of cadaverine

Recombinant microorganisms with deregulated succinyl-CoA synthetase activity, as well as the uses for producing lysine, &#x3b2;-lysine, cadaverine or N-acetylcadaverine thereby are provided. Recombinant polypeptides comprising an amino acid sequence being at least 80% identical to SEQ ID NO: 51 or 53 are also provided. The method of producing fine chemicals using said recombinant microorganisms, in particular the method of producing lysine, or derivatives thereof, such as &#x3b2;-lysine, cadaverine or N-acetylcadaverine is further provided.

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Braunschweig, Germany

Stefanie Kind