California Institute of Technology

Stefanie Heyden

Michael Ortiz

Morteza Gharib

Mikhail G Shapiro

David Reza Mittelstein

Systems and methods for targeting specific cell types by selective application of ultrasonic harmonic excitation at a resonance frequency ('oncotripsy') for the specific cell types are presented. The systems and the methods result in permeabilization, lysis, and/or death of the targeted specific cell types by using ultrasonic harmonic excitations that have a frequency and a pulse duration specifically tuned to disrupt nuclear membranes of the targeted specific cell types by inducing a destructive vibrational response therein while leaving non-targeted cell types intact. Target cells may be neoplastic.

Selective disruption of neoplastic cells via resonant harmonic excitation

Systems and methods for targeting specific cell types by selective application of ultrasonic harmonic excitation at their resonance frequency ('oncotripsy') are presented. The systems and methods result in the lysis of targeted cell types by using ultrasonic harmonic excitations that have been specifically tuned to disrupt the nuclear membrane of the targeted cells types by inducing a destructive vibrational response therein while leaving non-targeted cell types intact. The target cells types may be cancerous cells.

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Pasadena, CA, United States of America

Stefanie Heyden