Endo Pharmaceuticals Solutions Inc.

Braeburn Pharmaceuticals, Inc.

Stefanie Decker

Alexander Schwarz

Petr Kuzma

Harry Quandt

Peter Kuzma

Described herein are implantable devices, formulations and methods of making implantable devices for the release of a polypeptide from an implantable device, and methods of use thereof.

Method of manufacturing an implantable device

Methods, formulations and kits are described that allow for the controlled release of octreotide, e.g., octreotide acetate, in a subject.

Octreotide implant having a release agent

Implantable device for the sustained release of a polypeptide

Octreotide implant having a release agent and uses thereof

A formulation of octreotide or pharmaceutically acceptable salts thereof, which provides controlled release of a therapeutically effective amount of octreotide for a period of at least about two months. Methods of treating acromegaly, decreasing growth hormone, decreasing IGF-1, and treating conditions associated with carcinoid tumors and VIPomas by administering a controlled release formulation of octreotide are provided herein.

Controlled release formulations of octreotide

Methods and devices are described for delivering octreotide to a patient, comprising implanting a controlled release composition for delivering octreotide, wherein the composition does not require hydration prior to implantation, and wherein the composition optionally comprises a release agent.

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Princeton, NJ, United States of America

Stefanie Decker