Polichem S.a.

Nikem Research S.r.l.

Smithkline Beecham Corporation

Neurotune Ag

Other

Newron Pharmaceuticals S.p.a.

Dac S.r.l.

Smithkline Beecham Farmaceutici

Stefania Gagliardi

Carlo Farina

Federico Mailland

Michela Legora

Simone Del Sordo

Carlo Parini

Florian Thaler

Carla Ghelardini

Guy Marguerite Marie Gerard Nadler

Marisa Martinelli

Guy Marguerite Nadler

Anna Bulgheroni

Alessandra Consonni

Patricia Salvati

Mario Pinza

Saverio Minucci

Ciro Mercurio

Elena Colombo

Antonello Mai

Laura Faravelli

Marco Ballarini

Cibele Maria Sabido David

Gilles Pain

Silvio Massa

Shahzad Sharooq Rahman

Gaetano Gargiulo

Pier Giuseppe Pelicci

Andrea Colombo

Michel Jean Martin

Pietro A Novella

Pietro A T Novella

Marcel Jean-Marie Morvan

Silvano Ronzoni

(R)-Nifuratel is disclosed together with its use as bactericide and bacteriostatic agent as well as the pharmaceutical compositions containing the same; (R)-nifuratel has been surprisingly found to possess a better antimicrobial profile than either nifuratel racemate or (S)-nifuratel. A new procedure for the synthesis of both (R)-Nifuratel and (S)-Nifuratel is also disclosed.

(R)-Nifuratel, its use for the treatment of infections and synthesis of (R) and (S)-Nifuratel

The present invention provides secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested againstand. These compounds are active againstspecies such asand. 

Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents

The present invention provides new secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested againstand. Many of these compounds are active againstspecies such asand. 

Secondary 8-hydroxyquinoline-7-carboxamide derivatives

New tertiary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof are disclosed.  These compounds are useful as antifungal agents. Specifically, these compounds were tested againstand. These compounds are also active againstspecies such asand

Tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof

New histone deacetylase inhibitors according to the general formula (I) wherein: Q is a bond, CH, CH&#x2014;NRR, NRor oxygen, X is CH or nitrogen, Y is a bond, CH, oxygen or NR, Z is CH or nitrogen, R, Rare, independently, hydrogen, halogen, C-Calkyl or C-Chaloalkyl, R, Rare, independently, hydrogen or C-Calkyl, and R, R, Rand Rare as further defined in the specification.

Class of histone deacetylase inhibitors

Described herein are new bicyclic arylimidazolones having nootropic action (i.e., protecting and stimulating cerebral functions), analgesic action and anti hyperalgesic action; also described is the process for their preparation and pharmaceutical compositions comprising them, useful for the treatment of cognitive deficits, and of various types of pain.

Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof

Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents

This invention is related to compounds and use of N-Acyl-N'-benzyl-alkylendiamino derivatives of the following general formula (I), wherein A is a straight or branched C-Calkyl chain; X is a methylene, oxygen, sulphur or a NRgroup; Ris a straight or branched C-Calkyl or C-Calkenylene or C-Calkynylene chain, optionally substituted with CF, phenyl, phenoxy or naphthyl, the aromatic rings optionally substituted by one or more C-Calkyl, halogens, trifluoromethyl, hydroxy or C-Calkoxy groups; R, Rare independently hydrogen, a C-Calkyl chain, halogen, trifluoromethyl, hydroxy or C-Calkoxy groups; R, Rare independently hydrogen or C-Calkyl; Ris a hydrogen or a straight or branched C-Calkyl or linked to Rcan form a five to seven membered lactam; Ris hydrogen or C-Calkyl; and the pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role 

N-acyl-N'-benzyl-alkylendiamino derivatives

A compound of formula (I) or a salt thereof, or a solvate thereof, wherein: X represents oxygen, sulphur, or NR; Y and Z each independently represent nitrogen, CH, CRor CR; A represents an unsubstituted or substituted aryl group or an unsubstituted or substituted heterocyclyl group; Rrepresents &#x2014;C(O)NRR; Rand Reach independently represents hydrogen or specific substituents; and the use of such a compound in the treatment and/or prophylaxis of diseases associated with over activity of osteoclasts in mammals.

Azolylbenzamides and analogues and their use for treating osteoporosis

A compound of formula (I):or a salt thereof, or a solvate thereof, wherein Ra represents a group Rwhich is hydrogen, alkyl or optionally substituted aryl and Rb represents a moiety of formula (a):wherein X represents a hydroxy or an alkoxy group wherein the alkyl group may be substitued or unsubstituted or X represents a group NRRwherein Rand Reach independently represent hydrogen, alkyl, substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted arylalkyl, an optionally substituted heterocyclic group or an optionally substituted heterocyclylalkyl group, or Rand Rtogether with the nitrogen to which they are attached form a heterocyclic group; Rrepresents an alkyl or a substituted or unsubstituted aryl group; and R, Rand Reach independently represent hydrogen, alkyl, aryl or substituted aryl; Rand Reach independently represent hydrogen, hydroxy, amino, alkoxy, optionally substituted aryloxy, optionally substituted benzyloxy, alkylamino, dialkylamino, halo, trifluoromethyl, trifluoromethoxy, nitro, alkyl, carboxy, carbalkoxy, carbamoyl, alkylcarbamoyl, or Rand Rtogether represent methylenedioxy, carbonyldioxy or carbonyldiamino; and Rrepresents hydrogen, hydroxy, alkynoyl, alkyl, aminoalkyl, hydroxyalkyl, carboxyalky, carbalkoxyalkyl, carbamoyl or aminosulphonyl; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine.

Indole derivatives for the treatment of osteoporosis

Indole derivatives and their use for the treatment of osteoporosis amongst other applications

Indole derivatives useful A.O. for the treatment of osteoporosis

Heteroaromatic pentadienoic acid derivatives useful as inhibitors of

Indole derivatives useful in the treatment of osteoporosis

Growing community of inventors

Vimercate, Italy

Stefania Gagliardi