Bayer Aktiengesellschaft

Bayer Pharma Aktiengesellschaft

Stefan Wohlfeil

Martin Beuck

Ulrich E Muller

Rudolf H Hanko

Stanislav Kazda

Matthias Muller-Gliemann

Johannes-Peter Stasch

Andreas Knorr

Peter Fey

Thomas Kramer

Walter Hubsch

Jurgen Dressel

Hilmar Bischoff

Dirk Denzer

Siegfried Zaiss

Richard D Connell

Siegfried Goldmann

Rudi Grutzmann

Stefan Lohmer

Ozkan Yalkinoglu

Anke Domdey-Bette

Ulrich E M Uller

Matthias M uller-Gliemann

Claudia Hirth-Dietrich

Ulrich M&uuml;ller

J Urgen Dressel

Siegfried Raddatz

Michael Matzke

Ulrich Niewohner

Rudi Gr&uuml;tzmann

Walter H Ubsch

Thomas Kr Amer

Rolf Angerbauer

Klaus-Helmut Mohrs

Delf Schmidt

Erwin Bischoff

Gunter Schmidt

Christoph Gerdes

James J Elting

Klaus Mohrs

Arndt Brandes

Stephane Gero

Jeannine Cleophax

Georges Vass

Catherine Verre-Sebrie

Alice Olesker

Didier Dubreuil

Gabriele Hecker

Zhan Gao

Peter Kolkhof

Peter Eckenberg

Ulrich Nielsch

Ulrich Müller

Mauro Vieira De Almeida

Walter Husch

Mauro V De Almeida

Stanisiav Kazda

Hans-Peter Belleman

Rudi Grützmann

Rudi Gru Tzmann

Rudi Gr Utzmann

Hans-Peter Bellemann

Cycloalkano-indole and -azaindole derivatives are prepared by reaction of appropriately substituted carboxylic acids with amines. The cycloalkano-indole and -azaindole derivatives are suitable as active compounds for medicaments, preferably antiatherosclerotic medicaments.

Cycloalkano-indole and -azaindole derivatives

Cycloalcanoindole and -azaindole derivatives are prepared by reaction of appropriately substituted carboxylic acids with anmines. The cycloahloanindole and -azaindole derivatives are suitable as active compounds for medicaments, preferably antiatherosclerotic medicaments.

Cycloakano-indole and -azaindole derivatives are prepared by reaction of appropriately substituted carbonylic acids with amines. The cycloalkano-indole and -azaindole derivatives are suitable as active compounds for medicaments, preferably antiatherosclerotic medicaments.

The indolyl-substituted phenylacetic acid derivatives are prepared by reacting the corresponding phenylacetic acids with the required amines. The indolyl-substituted phenylacetic acid derivatives are suitable as active compounds in medicaments, in particular in antiarteriosclerotic medicaments.

Indolyl-substituted phenylacetic acid derivatives

The bicyclic heterocyclic compounds are prepared by reaction of correspondingly substituted carboxylic acids with amines, in particular with phenylglycinolamine. The bicyclic heterocyclic compounds according to the invention are suitable as active compounds in medicaments, in particular in medicaments having an antiatherosclerotic action.

Bicyclic heterocyclic compounds

The 2-aryl-substituted pyridines are prepared by reacting pyridylaldehydes with organometallic compounds and then selectively reducing the products. The 2-aryl-substituted pyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of arteriosclerosis.

2-aryl-substituted pyridines

The pyrimido[1,2-a]indoles according to the invention are prepared by reacting appropriately substituted phenylacetic acid derivatives with phenylglycinols. The pyrimido[1,2-a]indoles can be used as active compounds in medicaments, in particular in medicaments with antiatherosclerotic activity.

Pyrimido[1,2-a]indoles

The phenylcyclohexylcarboxamides, some of which are known, are suitable as active compounds in medicaments, in particular in medicaments for the treatment of restenosis.

Use of phenylcyclohexylcarboxamides

The heterocyclic aryl-, alkyl- and cycloalkylacetamides are prepared by reacting the appropriately substituted acetic acids with amines, if appropriate in complexed form. The heterocyclic aryl-, alkyl- and cycloalkylacetamides can be used as active compounds in medicaments, in particular in antiatherosclerotic medicaments.

Heterocyclic aryl-, alkyl- and cycloalkylacetamides

Trisubstituted biphenyls are prepared by reacting corresponding pyridones with biphenylmethyl halogen compounds. The trisubstituted biphenyls can be employed as active compounds in medicaments.

Trisubstituted biphenyls

Amides and sulphonamides of benzylamines having heterocyclic substituents are prepared by first converting the corresponding carboxylic acids into the corresponding amines and then substituting these on the amine nitrogen in a corresponding manner. The new amides and sulphonamides of benzylamines having heterocyclic substituents can be used as active compounds in medicaments, in particular in antiatherosclerotic medicaments.

Amides and sulphonamides of benzylamines having heterocyclic substituents

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Hilden, Germany

Stefan Wohlfeil