Sartorius Stedim Biotech Gmbh

Volkswagen Ag

Dwi—leibniz-institut Fur Interaktive Materialien E.v.

Stefan Weisshaar

Michael Bates

Martin Leuthold

Oscar-Werner Reif

Gerhard Greller

Alexander Mueller

Reinhard Baumfalk

Ulrich Grummert

Dieter Melzner

Thomas Krumbein

Dirk Lamprecht

Jens Ludwig

Daniel Riechers

Juergen Van Den Boogaard

Annette Reiche

Ute Husemann

Stefan Zeuch

Gerid Hellwig

Julia Lueders

Volker Limpert

Matthias Wessling

Guenter Pradel

Christian Pradel

Ute Noack

Christoph Schich

Günter Pradel

Peter Polossek

Ulrich Mähr

Juergen Van Den Boogard

Markus Haeusser

Manfred Gottlöber

Mario Deuse

Kristina Baitalow

Markus HÄUSSER

Jonas LÖLSBERG

Julia LÜDERS

Peter Pollosek

Jürgen Van Den Boogaard

Carsten Pretorius

Oliver Gronwald

A modular processing system () for biopharmaceutical processes includes (i) at least one first and at least one second processing unit (), which can be fluidically connected to each other; and (ii) at least one adapter plate (), through which at least one fluid flow (), flowing from the first processing unit () to the second processing unit (), can flow. The adapter plate deflects the fluid flow between the first processing unit and the second processing unit at least partially; and/or controls the fluid flow, preferably, the pressure thereof, in an open loop or closed loop manner. A method for the modular construction of a processing system () for biopharmaceutical processes is also disclosed.

Modular processing system and method for the modular construction of a processing system

A configurable device arrangement for performing at least one unit operation in a biopharmaceutical process includes a base rack and a plurality of holders for releasable direct or indirect attachment of process components, in particular single-use process components, for the unit operation. The holders are in turn adapted to be releasably attached directly or indirectly to the base rack. The device arrangement further includes a positioning system which defines specific positions for the holders relative to the base rack.

Configurable device arrangement for performing at least one unit operation in a biopharmaceutical process

A mixing apparatus () for mixing a fluid and/or solid. The mixing apparatus includes a mixing container () having an interior in which the fluid and/or solid can be arranged. A feed-through passage () extends through a container wall () of the mixing container. A drive shaft () is fed through the feed-through passage, to drive a stirring element () arranged at least partly in the interior of the mixing container. The stirring element is used to mix the fluid and/or solid arranged in the mixing container. A drive-side shaft end () of the drive shaft couples the drive shaft to a drive () arranged outside of the mixing container. An adjustable seal () seals off the feed-through passage. A setting apparatus () is provided to switch the adjustable seal into at least two sealing operation states having different sealing effects.

Mixing apparatus and method for operating a mixing apparatus

Filter cassette

A connecting system () has at least one connector () for a filter cassette () that can be inserted into a filter holder and has filter layers () between two end plates (), and seals () between the filter layers () and/or between the end plates () and an adjacent filter layer (). The connector has tensioning parts that engage in one another in a longitudinally displaceable manner and that can be fixed to the end plates () via their ends facing away from one another. The connector exerts a pretensioning force onto the end plates () when it is deflected to its maximum extent. The pretensioning force pulls the end plates () towards the filter layers (), and when a contact-pressure force superimposed on the pretensioning force is applied to the end plates (), the tensioning parts can be pushed towards one another correspondingly with the end plates ().

Connecting system for filter cassettes

Aeration device for bioreactors with an aeration element with gas outlet openings arranged in a housing, the aeration element taking the form of a microsparger, the gas outlet openings of which are in each case spaced apart from one another and have a size of between 100 &#x3bc;m and 200 &#x3bc;m. At least one second aeration element with gas outlet openings of a second size is preferably provided, the aeration elements being formed by a common housing with separate aeration channels.

Aeration device for bioreactors

One aspect of the invention relates to a filter module comprising: &#x2014;a filter element having at least one filter medium which separates a filtrate side and a retentate side of the filter element from one another, and having a filter medium holder to which the filter medium is attached and which has at least one holder intake channel and at least one holder discharge channel, &#x2014;a first filter cartridge part having at least one first cartridge intake channel and at least one first cartridge discharge channel, &#x2014;a second filter cartridge channel having at least one second cartridge intake channel and at least one second cartridge discharge channel, wherein the filter medium holder is arranged in an arrangement position between the first filter cartridge part and the second filter cartridge part in a fluid-tight manner, wherein the at least one holder intake channel has a fluid connection with the at least one first cartridge intake channel and the at least one second cartridge intake channel, in order to form a module intake channel, wherein the at least one holder discharge channel has a fluid connection with the at least one first cartridge discharge channel and the at least one second cartridge discharge channel, in order to form a module discharge channel, wherein the module intake channel has a fluid connection with the retentate side of the filter medium and wherein the module discharge channel has a fluid connection with the filtrate side of the filter medium, and a modular filter system.

Filter module and modular filter system

Aeration device for bioreactors with a first aeration element with gas outlet openings of a first size and with at least one second aeration element with gas outlet openings of a second size, the aeration elements being formed by a common housing with separate aeration channels.

The invention relates to a plate heat exchanger comprising a plurality of plates having flow channels, wherein a first plate has a front side having at least one flow channel for a first fluid and a second plate has a front side having at least one flow channel for a second fluid, and wherein the plates have through openings via which the flow channels for the same fluid are respectively connected to one another, wherein a front plate, which is placed in front of the front side of the first plate, has ports for the first fluid and for the second fluid, wherein an end plate forms the end of the aligned plates, wherein the plates and ports are formed from plastic, and wherein the plates are bonded or welded tightly together.

Plate heat exchanger

Filter assembly

A sensor device has an optical sensor (), a container () and a compartmentalizer () that temporarily divides the container into a main space () and an adjacent space (), in which the optical sensor () is located. The gas volume in the direct vicinity of the optical sensor () is reduced, as are also, consequently, the reactive products generated by radiation sterilization. The adjacent space () can be united with the main space () after the sterilization as a result of the temporary compartmentalization. The optical sensor is suitable for implementation in containers and laboratory products, such as, for example, disposable bioreactors, that are sterilized by gamma radiation.

Sensor device, comprising an optical sensor, a container and a compartmentalization means

A sensor protector is intended to reduce the sensitivity of the optical sensor () to radiation products which, for example, are formed during sterilization with gamma radiation and to ensure simple and cost-effective manufacture. The sensor protector includes an upper part (), a lower part () and an optical sensor (). The optical sensor () situated on the lower part is positionable in an offset manner with respect to an opening () situated in the upper part and movable by means of displacement toward the opening () of the upper part (). The sensor protector is suitable for use in containers and laboratory products that are sterilized by gamma radiation, for example disposable bioreactors.

Sensor protector

The invention relates to a waste gas system for bioreactors having a hydrophobic sterile filter, arranged at the end, and a heat exchanger which protects the sterile filter against blocking by liquid media. The gas outflow duct for discharging waste gas from a bioreactor vessel is divided in a cooling zone of the heat exchanger into a multiplicity of subducts and is extended in a heating zone of the heat exchanger to a calming zone. Due to the multiplicity of subducts, a considerably larger surface area for the removal of heat from the waste gas is available, with the result that in the case of laminar flow of the waste gas through the subducts a high effectiveness of the separation of liquids from the waste gas can be achieved. In the heating zone, the waste gas can heat up again due to the reduced flow rate until it reaches the hydrophobic sterile filter by way of taking up heat from the surroundings to a such a degree that the relative vapor contents are below 100% and separation of liquids from residual vapors at or in the hydrophobic sterile filter is precluded.

Waste gas system for bioreactors

Growing community of inventors

Adelebsen, Germany

Stefan Weisshaar