Bayer Aktiengesellschaft

Hoffmann-la Roche Inc.

Bayer Healthcare Aktiengesellschaft

Aicuris Gmbh + Co. Kg.

Bayer Intellectual Property Gmbh

Bayer Schering Pharma Ag

Bayer Aktiengeselischaft

F. Hoffmann-la Roche Ag

Stefan Weigand

Johannes-Peter Stasch

Frank Wunder

Elke Stahl

Cristina Alonso-Alija

Achim Feurer

Alexander Straub

Dieter Lang

Klaus Dembowsky

Dietmar Flubacher

Elisabeth Perzborn

Guy Georges

Rainer Endermann

Erwin Bischoff

Siegfried Raddatz

Matthias Koerner

Ulrike Reiff

Klaus Münter

Martin Michels

Yolanda Cancho-Grande

Kerstin Ehlert

Andreas Knorr

Frederick Arthur Brookfield

Wolfgang Schaefer

Volkhart Min-Jian Li

Markus Follmann

Joachim Schuhmacher

Michael Hahn

Thomas Lampe

Nils Griebenow

Gorden Redlich

Josef Pernerstorfer

Lars Bärfacker

Klaus Kaluza

Stefan Scheiblich

Edward Andrew Boyd

Wolfgang Von Der Saal

Jens Ackerstaff

Yolanda Cancho Grande

Hanno Wild

Thomas Krahn

Petra Rueger

Edgar Voss

Matthias Rueth

Jens-Kerim Ergüden

Eike Hoffmann

Christoph Freiberg

Isabelle Adelt

Irene Kolm

Bernhard Goller

Michael Brands

Elizabeth Perzborn

Christine Schuell

Justin Warne

Christian Schröder

Sabine Huensch

Klaus Muenter

The present application relates to novel bicyclic azaheterocycles, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.

Bicyclic aza heterocycles, and use thereof

Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer. 

Pyrimidyl derivatives as protein kinase inhibitors

Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer. 

Benzimidazole amido derivatives as kinase inhibitors

The invention relates to compounds of formula (I) and their salts and stereoisomers in which the variables are as defined in the description and claims, for producing medicaments used in the treatment of cardiovascular and other diseases. Such compounds, processes for preparing them, compositions containing them, and methods of using them are claimed.

Substituted aminodicarboxylic acid derivatives having pharmaceutical properties

The invention relates to antibacterial macrocycles with substituted biphenyl and processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially of bacterial infections.

Antibacterial macrocycles with substituted biphenyl

The invention relates to antibacterial amide macrocycles and processes for their preparation, their use for the treatment and/or prophylaxis of diseases and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially bacterial infections.

Antibacterial amide macrocycles IV

This invention relates to methods of treatment of cardiovascular disorders, thromboembolic disorders, inflammation, and disorders of the central nervous system using pyrazol pyridine derivatives of formula (I) wherein Ris a radical of the formula &#x2014;O&#x2014;SO&#x2014;Rin which Ris optionally substituted C-alkyl, optionally substituted C-cycloalkyl, or optionally substituted phenyl; Ris H, optionally substituted C-alkyl-CO&#x2014; or optionally substituted C-alkyl-SO&#x2014;; as well as salts, stereoisomers, tautomers, and hydrates thereof.

Methods of treating medical conditions using sulfonate-substituted pyrazolopyridine derivatives

This invention relates to methods for treating sexual dysfunction, by administering a compound of the formula wherein Ris H or a di-C-alkylaminocarbonyl radical, and Ris a radical of the formula &#x2014;O&#x2014;C(X)&#x2014;NRRwherein X is O or S. The compound may also be administered in combination with at least one organic nitrate or NO donor, or in combination with at least one compound which inhibits the breakdown of cyclic guanosine monophosphate (cGMP).

Medical uses of carbamate-substituted pyrazolo-pyridine derivatives

Compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates are disclosed. Also disclosed are methods for the preparation of the above-mentioned compounds, pharmaceutical compositions containing them, as well as the use of the above-mentioned compounds in the treatment, control or prevention of illnesses such as cancer.

Phthalazinone derivatives

The present invention relates to compounds which stimulate soluble guanylate cyclase, to the preparation thereof and to the use thereof as medicaments, in particular as medicaments for the treatment of cardiovascular disorders and/or sexual dysfunction.

Carbamate-substituted pyrazolopyridines

This application relates to compounds of the formula (I) 

Derivatives of 2-(1-benzyl-1H-pyrazolo(3,4-B)pyridine-3-yl)-5(-4-pyridinyl)l-4-pyrimidinamines and the use thereof as quanylate cyclase stimulators

This invention relates to compounds of the formula in which R, R, and Rare as defined in the claims, to a process for preparing such compounds, to pharmaceutical compositions containing such compounds, and to methods of using such compounds for treatment of hypertension and sexual dysfunction.

Sulfonamide-substituted pyrazolopyridine compounds

This invention relates to compounds of the formulawherein Ris H or a di-C-alkylaminocarbonyl raical, and Ris a radical of the formula &#x2014;O&#x2014;C(X)&#x2014;NRRwherein X is O or S. A process for preparing such compounds, pharmaceutical compositions containing them, and methods for using them in treatment of hypertension are also disclosed and claimed.

Carbamate-substituted pyrazolopyridine-derivatives

The invention relates to compounds of formula (I), to a method for the production thereof, and to the use of the same as pharmaceuticals for the treatment of diseases in humans and/or animals 

Substituted 2,5-diamidoindoles as ECE inhibitors for the treatment of cardiovascular diseases

This invention relates to pyrazol pyridine derivatives of formula (I)wherein Ris a radical of the formula &#x2212;O&#x2014;SO&#x2014;Rin which Ris optionally substituted C&#x2014;alkyl, optionally substituted C&#x2014;cycloalkyl, or optionally substituted phenyl; Ris H, optionally substituted C&#x2014;alkyl &#x2014;CO&#x2014;or optionally substituted C&#x2014;alkyl&#x2014;SO&#x2014; ; as well as salts, stereoisomers, tautomers, and hydrates thereof. Pharmaceutical compositions containing these materials and methods of using them in medical treatment are also described and claimed.

Sulfonate substituted pyrazol pyridine derivatives

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Wuppertal, Germany

Stefan Weigand