Heraeus Precious Metals Gmbh & Co. Kg

Medac Gesellschaft Fur Klinische Spezialpraparate Mbh

Stefan Wallert

Tero Kunnari

Holger Bindernagel

Andrew Lupton

Sascha Weiser

4'-epidaunorubicin hydrochloride is provided in a crystalline form which is stable and readily soluble. A process of producing the crystalline form includes crystallizing 4&#x2032;-epidaunorubicin hydrochloride in a solvent system including (a) solvent A selected from Cand Chalogenated solvents and mixtures thereof, (b) solvent B selected from C-Cstraight and branched alcohols and mixtures thereof, and (c) solvent C selected from C-Cstraight and branched alcohols and mixtures thereof, wherein solvent C is selected to provide lower solubility to 4&#x2032;-epidaunorubicin hydrochloride than solvent B. A method of producing an anthracycline using crystalline 4&#x2032;-epidaunorubicin hydrochloride is also provided.

Crystalline 4'-epidaunorubicin hydrochloride and use thereof

4'-epidaunorubicin hydrochloride is provided in a crystalline form which is stable and readily soluble. A process of producing the crystalline form includes crystallizing 4&#x2032;-epidaunorubicin hydrochloride in a solvent system including (a) solvent A selected from Cand Chalogenated solvents and mixtures thereof, (b) solvent B selected from C-Cstraight and branched alcohols and mixtures thereof, and (c) solvent C selected from C-Cstraight and branched alcohols and mixtures thereof, wherein solvent C is selected to provide lower solubility to 4&#x2032;-epidaunorubicin hydrochloride than solvent B.

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Seligenstadt, Germany

Stefan Wallert