North Carolina State University

Other

Mannkind Corporation

Premitec, Inc.

Doheny Eye Institute

Sicel Technologies, Inc.

Dohey Eye Institute

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Ufer, Stefan

Stefan Ufer

Helmut Eckhardt

Mark Salman Humayun

James David Weiland

Thomas Hofmann

Hossein Ameri

Kevin Stapleton

Helmut Eckhard

Jerome J Cuomo

Jason Oliver Fiering

Christopher Douglas Wilsey

Bahram Ghaffarzadeh Kermani

Charles W Scarantino

H Troy Nagle

Chang-Soo Kim

Tenapat Ratanapakorn

Tanapat Ratanapakorn

The present invention relates to pharmaceutical compositions for inhalation comprising a therapeutically effective dose of clofazimine wherein the clofazimine is provided in the form of a suspension, and processes for their preparation. Furthermore, the present invention provides pharmaceutical combinations comprising clofazimine in the form of an aerosol for pulmonary inhalation. The combinations and compositions provided by the present invention may be used in the treatment and/or prophylaxis of pulmonary infections caused by mycobacteria and other gram-positive bacteria, and of pulmonary fungal infections.

Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them

A packaged electronic device includes a flexible circuit structure and a die. The flexible circuit structure includes a first structural layer and electrical conductors. The die is bonded to the flexible circuit structure by a flexible attachment layer. The die includes interconnects in electrical contact with die circuitry and extending through the die, through the flexible attachment layer, and into electrical contact with respective electrical conductors at first ends. A flexible second structural layer is disposed on the die and exposed portions of the electrical conductors, wherein the die and the electrical conductors are encapsulated by the first structural layer and the second structural layer. The first structural layer and/or the second structural layer include a plurality of openings defining respective exposed areas on the electrical conductors at second ends.

Flexible electronic devices and related methods

A wide-filed retinal prosthesis enables an increased field of vision with a relatively small scleral incision. The retinal prosthesis includes a flexible substrate comprising a central member and at least one wing, with an array of electrodes disposed therein that are configured to stimulate the central and peripheral nerves of the retina.

Wide-field retinal prosthesis

A packaged electronic device includes a die, a flexible circuit structure, and a barrier film disposed on the die. The die includes die circuitry and electrical contacts. The flexible circuit structure is bonded directly to the die, and includes electrical conductors encapsulated by structural layers. Each electrical conductor contacts a respective electrical contact. The electronic device is encapsulated by the barrier film and one or more of the structural layers.

Fabrication of electronic devices including flexible electrical circuits

Electronic devices including flexible electrical circuits and related methods

Calibration of in vivo oxygen and pH sensor systems can be performed by generating a constituent element of an environment proximate to an in vivo sensor electrode via an in vivo generating electrode and determining a level of the constituent element in the tissue via the in vivo sensor electrode. Accordingly, accurate monitoring of tissue can be achieved while reducing the need to calibrate the in vivo sensor systems using invasive procedures. Related electrode assemblies are also discussed.

Methods, computer program products, and devices for calibrating chronically tissue implanted sensors using chronically tissue

Chemical sensors include a flexible substrate, a flexible lower electrode on the flexible substrate, and a patterned flexible dielectric layer on the flexible lower electrode opposite the flexible substrate. A patterned flexible upper electrode also is included on the patterned flexible dielectric layer opposite the flexible lower electrode. The patterned flexible dielectric layer and the patterned flexible upper electrode are patterned to establish a first current flow path between the flexible lower electrode and the patterned flexible upper electrode through the chemical, if present, upon application of voltage between the flexible lower electrode and the patterned flexible upper electrode. The flexible lower electrode also may be patterned to establish a second current flow path between portions of the patterned flexible lower electrode through the chemical, if present, upon application of voltage between the portions of the patterned flexible lower electrodes. The flexible upper electrode also may be patterned to establish a third current flow path between portions of the patterned flexible upper electrode through the chemical, if present, upon application of voltage between the portions of the patterned flexible upper electrode. A rigid substrate also may be used.

2D/3D chemical sensors and methods of fabricating and operating the same

A method of forming a laminate structure comprises providing a first substrate and a second substrate each having first and second substrate surfaces respectively, and wherein the surfaces are present in an opposed spaced apart relationship; contacting at least one of the first or second substrate surfaces with a release material such that a portion of the first or second substrate surface is covered with the release material while the remainder of the first or second substrate surface is not covered with the release material; bringing the first and second substrate surfaces of the first and second substrates into contact with each other; and subjecting the substrates to conditions such that the portions of the first and second substrate surfaces not covered with release material become bonded to one another and a laminate structure is formed. The portion of the first or second substrate surface covered with the release material allows the first and second substrates to separate from each other such that an opening is formed therebetween that is substantially coincident with the portion covered with the release material.

Pattern release film between two laminated surfaces

Growing community of inventors

Raleigh, NC, United States of America

Stefan Ufer