Asta Medica, Aktiengesellschaft

Elbion Ag

Biotie Therapies Corporation

Asta Medica Aktiengesellschgt

Stefan Szelenyi

Bernhard Kutscher

Jurgen Engel

Peter Emig

Emmanuel Polymeropoulos

Ute Egerland

Degenhard Marx

Thomas Kronbach

Hildegard Kuss

Ilona Fleischhauer

Guillaume Lebaut

Kay Brune

Norbert Höfgen

Bernd Nickel

Ulrich Werner

Hans-Reinhold Dieter

Ute Achterrath-Tuckermann

Jurgen Schmidt

Peter Metzenauer

Gerhard Scheffler

Heinz Ulrich

Sabine Heer

Gabriela Pergande

Georg Niebch

Cécilia Menciu

Karl-Heinz Klingler

C&eacute;cilia Menciu

Ute Achterath-Tuckermann

Emanuel Polymeropoulos

Thomas Buchner

Norbert Hofgen

Michael Schwarz

Fabienne Fouchard

7-azaindoles inhibit phosphodiesterase 4 (PDE4). Methods for preparing these compounds and methods of treating arthritis and other conditions with the compounds are also provided.

7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them

7-azaindoles inhibit phosphodiesterase 4 (PDE4). Methods for preparing these compounds are also provided.

The invention relates to new 7-azaindoles, their use as inhibitors of phosphodiesterase 4 and to methods for their synthesis.

7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same

The invention relates to novel N-substituted indole-3-glyoxylamides, to processes for their preparation and to their pharmaceutical use. The compounds have antiasthmatic, antiallergic and immuno-suppressant/immunomodulating actions.

N-substituted indole-3-glyoxylamides having anti-asthmatic, antiallergic and immunosuppressant/immuno-modulating action

Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and process for their preparation

The invention relates to novel N-substituted indole-3-glyoxylamides, to processes for their preparation and to their pharmaceutical use. The compounds have antiasthmatic, antiallergic and immunosuppressant/immunomodulating actions.

N-substituted indole-3 glyoxylamides having anti-asthmatic antiallergic

N-benzylindole and benzopyrazole derivatives with anti-asthmatic,

The invention relates to novel pyrido�3,2-e!pyrazinones, processes for their preparation and their pharmaceutical use. The compounds have anti-asthmatic and anti-allergic effects.

Pyrido �3,2-E!pyrazinones with anti-asthmatic action and processes for

Primary and secondary neuroprotective effect of flupirtine in

Phthalazinone derivatives and their optical isomers are used as medications to combat heart rhythm disturbances, to combat pain and to break through multi-drug resistance.

Phthalazinone derivatives that modulate multi-drug resistance

6-amino carboxylic acid derivatives having antiasthmatic and antiallergic properties which can be used for the preparation of medicaments. The compounds have the formula: ##STR1## wherein R.sub.1 and R.sub.2 represent hydrogen, a straight-chain or branched alkyl radical with 1-6 carbon atoms, benzyl or phenylethyl, R.sub.3 represents hydrogen, a straight-chain or branched alkyl radical with 1-6 carbon atoms or benzyl, X represents hydrogen, halogen, C.sub.1 -C.sub.6 -alkyl or C.sub.1 -C.sub.6 -alkoxy, Y.sub.1 and Y.sub.2 represent hydrogen, halogen, C.sub.1 -C.sub.6 -alkyl or C.sub.1 -C.sub.6 -alkoxy, where m, n and o can assume the values from 0-4.

Aminocarboxylic acid derivatives having antiallergic/antiasthmatic

Novel compounds of the formula ##STR1## where the phenyl ring can also contain a nitrogen atom instead of a CH group, R.sub.1 is C.sub.2 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -alkynyl, hydroxy, C.sub.1 -C.sub.6 -alkoxy, C.sub.3 -C.sub.6 -alkenyloxy, C.sub.3 -C.sub.6 -alkynyloxy, C.sub.2 -C.sub.6 -alkanoyloxy, benzoyloxy, morpholinocarbonyloxy, C.sub.1 -C.sub.6 -alkyloxycarbonyloxy, C.sub.1 -C.sub.6 -alkylaminocarbonyloxy, C.sub.1 -C.sub.6 -dialkylaminocarbonyloxy or the group -Alk-A, where Alk represents C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -hydroxyalkyl or C.sub.3 -C.sub.6 -cycloalkyl and the symbol A represents hydrogen or other substituents. R.sub.2, R.sub.3 and R.sub.4 represent various substituents, where R.sub.1 may also be hydrogen, when R.sub.2 is the group ##STR2## and R.sub.5 represents phenyl, C.sub.1 -C.sub.4 -alkoxyphenyl or diphenylmethyl and R.sub.3 and R.sub.4 are hydrogen and their salts. The compounds provide anti-allergic, anti-asthmatic, anxiolytic and hypotensive effects.

4,5-dihydro-4-oxo-pyrrolo[1,2-a]quinoxalinones and corresponding aza

Pharmacologically active 1,2,4-triaminobenzene derivatives of the General Formula I: ##STR1## where the symbols R1' R2' R3' R4' R5' Ar and Alk have the following meanings: where the symbols R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, Ar and Alk have the following meanings:

Pharmaceutically active 1,2,4-triamino-benzene derivatives, processes

Pharmacologically active compounds of the General Formula ##STR1## where X is oxygen or sulphur and the radical R represents a quinuclidyl radical, an C.sub.1 -C.sub.6 -alkyl radical, a phenyl radical, a pyridyl radical, a phenyl or pyridyl radical substituted by the radicals R.sub.1, R.sub.2, and/or R.sub.3, a C.sub.1 -C.sub.6 -alkyl radical substituted by pyridyl or alkylpyridyl or a C.sub.1 -C.sub.6 -alkyl radical substituted by phenyl, where each phenyl radical may also be substituted by the radicals R.sub.1, R.sub.2 and/or R.sub.3 and the radicals R.sub.1, R.sub.2 and R.sub.3 are the same or different and represent hydrogen, halogen, trihalogenmethyl, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, carboxy, Carb-C.sub.1 -C.sub.6 -alkoxy, amino, C.sub.1 -C.sub.6 -alkylamino, C.sub.1 -C.sub.6 -dialkylamino, C.sub.1 -C.sub.6 -trialkylamino, C.sub.2 -C.sub.6 -alkanoylamino, or C.sub.2 -C.sub.6 -alkanoylamino which contains one more amino group in the alkyl portion, and their physiologically acceptable acid addition salts. The compounds provide analgesic, anti-inflammatory, anti-convulsive and anti-pyretic effects.

Phthalazines containing an aromatic ether or thioether group in the

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Schwaig, Germany

Stefan Szelenyi