Med-el Elektromedizinische Geraete Gmbh

Stefan Strahl

Philipp Spitzer

Konrad Eugen Schwarz

Claude Jolly

Martin Zimmerling

Anandhan Dhanasingh

Marek Polak

Cornelia Falch

Angelika Dierker

Tanja Schulze

A system and method detect neuronal action potential signals from tissue responding to electrical stimulation signals. A sparse signal space model for a set of tissue response recordings has a signal space separable into a plurality of disjoint component manifolds including a neural action potential (NAP) component manifold corresponding to tissue response to electrical stimulation signals. A response measurement module is configured to: i. map a tissue response measurement signal into the sparse signal model space to obtain a corresponding sparse signal representation, ii. project the sparse signal representation onto the NAP component manifold to obtain a sparse NAP component representation, iii. when the sparse NAP component representation is greater than a minimum threshold value, report and recover a detected NAP signal in the tissue response measurement signal.

Detecting neuronal action potentials using a sparse signal representation

A hearing implant fitting system includes a physiological database containing physiological data characterizing auditory neural tissue response to electrical stimulation. A neural action potential (NAP) measurement system measures NAP signals from cochlear tissue responding to electrical stimulation signals delivered by one or more of the electrode contacts, including: deriving a compound discharge latency distribution (CDLD) of the cochlear tissue by deconvolving: (1) a tissue response measurement signal taken responsive to the delivered electrical stimulation signals, with (2) an elementary unit response signal representing voltage change at a measurement electrode contact due to the electrical stimulation, and then comparing the CDLD to physiological data from the physiological database to detect an NAP signal from the tissue response measurement signal. A fitting display provides to the fitting audiologist a visual display representing the CDLD and the NAP signal for fitting the electrode array to an implanted patient.

Detecting neuronal action potentials using a convolutive compound action potential model

Arrangements are described for determining a physiological characteristic of the auditory pathway (as whole or selected parts such as an inner ear). Electrical stimulation pulses are delivered to inner ear neural tissue and corresponding tissue response signals are developed by measuring over time response of the auditory pathway to each electrical stimulation pulse, with each tissue response signal forming a response curve including at least one physiological landmark such as a local maximum and a local minimum. A multi-dimensional polynomial is fit over the tissue response signals, and calculation starting points are defined based on prominent physiologic landmarks such as a local maximum and a local minimum for one selected tissue response signal. A line of minimum principal curvature of the multi-dimensional polynomial over the plurality of tissue response signals that intersect the calculation starting points is calculated to determine a physiological characteristic of the auditory pathway.

Determination of neuronal action potential amplitude based on multidimensional differential geometry

An audio-cochlear implant processor device for a hearing impaired listener is described. An input signal decoder decodes an audio input data signal into a corresponding multi-channel audio signal representing multiple audio objects. An audio processor adjusts the multi-channel audio output based on user-specific hearing impairment characteristics to produce a processed audio output to a cochlear implant audio processor with auditory scene analysis (ASA) cues for the hearing impaired listener.

Multi-channel object-oriented audio bitstream processor for cochlear implants

A cochlear implant electrode includes an implantable array carrier made of flexible material with electrode contacts distributed on its outer surface along a longitudinal axis. Electrode wires are embedded within the array carrier, each electrode wire having a terminal end electrically connected to a corresponding electrode contact for applying electrical stimulation signals carried by the electrode wires to adjacent neural tissue within the cochlea. Each electrode wire has an inner non-crystal conductive material surrounded by a flexible outer seal. The flexible material of the array carrier is configured to be reactive with the non-crystal conductive material of the electrode wires so that if a break occurs in the outer seal of an electrode wire that allows contact between the flexible material and the non-crystal conductive material, then a local leakage seal will form at the break that resists migration of the non-crystal conductive material to the outer surface of the array carrier.

Cochlear implant electrode with liquid metal alloy

A method is described for processing an electrical stimulation response measurement waveform signal measured in response to delivery of a selected electrical stimulation signal to neural tissue. The electrical stimulation response measurement waveform signal contains a stimulus artifact and one or more neuronal action potentials. The electrical stimulation signal is selected based on satisfying a cost function comparison between at least one stimulus artifact component and a plurality of known neuronal action potential waveforms. The electrical stimulation response waveform signal is then processed using a source separation algorithm to remove the stimulus artifact component.

Stimulus artifact removal for neuronal recordings

An arrangement is described for fitting a hearing prosthesis system to a prosthesis patient. The PAMR measurement determines a post-auricular muscle reflex (PAMR) response of the patient to an auditory stimulus signal. For example, the PAMR response may include a PAMR amplitude growth function or a PAMR threshold stimulus level at which a PAMR is measured in the patient. Then a patient fitting module sets an operating characteristic of the hearing prosthesis system based on the PAMR response.

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Innsbruck, Austria

Stefan Strahl