Pierre Fabre Medicament

Stefan Stanghl

Mathias Uhlen

Thien Ngoc Nguyen

Per-ANGke Nygren

Marianne Hansson

Tripartite recombinant DNA encoding fusion proteins which comprise three sequences, i.e., a signal peptide which is operable in a Gram positive bacterium, an immunogenic polypeptide linked thereto which is not normally expressed in a Gram positive bacterium, and a cell wall spanning and a membrane anchoring sequence, as well as their use in Gram positive bacteria to express the resultant fusion protein on their surface are described. The preferred cell wall spanning and anchoring polypeptides include Staphylococcus protein A and Streptococcus protein G.

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Gorvik, Sweden

Stefan Stanghl