Albemarle Germany Gmbh

Stefan Schnippering

Ulrich Wietelmann

Uwe Lischka

Peter Rittmeyer

Dirk Dawidowski

Annika Hörberg

Nikzad Nikbin

Johannes Klösener

Theresa Schmidt

Gary John Tarver

The object of the invention are solutions of alkali metal amides MNRR, wherein M is an alkali metal selected from Li, Na, K, Rb, Cs; Rand Rindependently of one another are linear, branched or cyclic alkyl groups having 1 to 8 C atoms or together are a cycloalkyl radical, the alkali metal amides being present in methyltetrahydropyran or in a solvent mixture containing methyltetrahydropyran, and processes for their preparation.

Stable alkali amide solutions and processes for preparing same

The invention relates to methods for CC bond formation using organolithium compounds under continuous flow conditions in a micro or mesoreactor system, wherein an organic substrate is reacted with an alkyl lithium compound in the presence of a donor solvent to form a Li intermediate, which can be reacted in situ or subsequently in a second reaction step with an electrophile to form an organic secondary product, the organolithium compound RLi being used as a solution in a hydrocarbon or hydrocarbon mixture and the RLi concentration being at least 3 M, preferably at least 4 M.

Organolithium process under continuous flow conditions

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Siegburg, Germany

Stefan Schnippering