Csl Behring Gmbh

Csl Limited

Nordmark Arzneimittel Gmbh & Co. Kg

Stefan Schmidbauer

Andrew Donald Nash

Marc Nolte

Con Panousis

Veronika Rayzman

Stefan Schulte

Hubert Metzner

Michael Wilson

Thomas Weimer

Manfred Kurfürst

Ulrich Kronthaler

Kay Hofmann

Lars Robbel

Manfred Kurfurst

The invention relates to inhibitory anti-factor XII/FXIIa antibodies and methods of their use.

Methods of administering inhibitory anti-factor XII/XIIa monoclonal antibodies

Methods of administering inhibitory anti-factor XII/XIIA monoclonal antibodies

Nucleic acids encoding inhibitory anti-factor XII/XIIa monoclonal antibodies

Inhibitory anti-factor XII/XIIA monoclonal antibodies and their uses

The present invention relates to the therapeutic application of the Kazal-type serine protease inhibitor Infestin or domains thereof or modified Kazal-type serine protease inhibitors based on Infestin homologs, which prevent the formation and/or stabilization of three-dimensional arterial or venous thrombi by interfering with proteins involved in activation of the so-called intrinsic coagulation pathway. The present invention also relates to the use of Kazal-type serine protease inhibitors or fragments thereof or modified Kazal-type serine protease inhibitors in the treatment or prophylaxis of a condition or disorder related to arterial thrombus formation, i.e. stroke or myocardial infarction, inflammation, complement activation, fibrinolysis, angiogenesis and/or diseases linked to pathological kinin formation such as hypotonic shock, edema including hereditary angioedema, bacterial infections, arthritis, pancreatitis, or articular gout, Disseminated Intravasal Coagulation (DIC) and sepsis.

Therapeutic application of Kazal-type serine protease inhibitors

The invention relates to a method for purifying at least one enzyme obtained in an excess fermentation of It is provided for that the enzymes of the excess fermentation are separated by a multistage chromatography method by exclusively using chromatography materials on styrene/divinyl-benzene base and/or on base of in particular ceramic hydroxylapatite.

Method for purifying enzymes from clostridium histolyticum using multi-stage chromatography

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Lahntal, Germany

Stefan Schmidbauer