Hoffmann-la Roche Inc.

American Cyanamid Company

Basf Aktiengesellschaft

F. Hoffmann-la Roche Ag

Stefan Scheiblich

Thomas Maier

Helmut Siegfried Baltruschat

Konrad Honold

Wolfgang Schaefer

Axel Kleemann

Birgit Masjost

Petra Rueger

Frederick Arthur Brookfield

Klaus Kaluza

Edward Andrew Boyd

Kin-Chun Thomas Luk

Thomas Von Hirschheydt

Richard Engh

Guy Georges

Gary Mitchell Karp

Uwe Josef Vogelbacher

Sung-Sau So

Michael E Condon

Wolfgang Von Der Saal

Matthias Koerner

Ulrike Reiff

Georg Tiefenthaler

Edgar Voss

Stefan Weigand

Matthias Rueth

Nikolaos Dimoudis

Jan Hendrik Wevers

Joseph Luke Pont

Thomas Hoellmueller

Manfred Schwaiger

Hubert Hertenberger

Jianping Cai

Pamela Loreen Rossman

Trevor W Newton

Axel Kleeman

Bernhard Goller

Robert Francis Doehner, Jr

Jonathan Gridley

Robert J H Scheffer

Andreas Pfrengle

Raymond Lau

Christine Schuell

Justin Warne

Isabel Waldeck

Barbara Klughammer

Thekla Haselwander

Hilke Sudergat

Guillemette Duchateau-Nguyen

Thekla Hulsen

Halmut Siegfried Baltruschat

Laurent Essioux

Hanno Langen

Jane Paul

Carl Roeschlaub

Alan Whittle

Peter Johannes Servaas Savio Van Eijk

Sabine Huensch

Oliver Tonn

Angélique Augustin

Sabrina Golling

Manuel Tzouros

Jens Lamerz

Hélène Meistermann

Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

Imidazo [4,5-B] pyridine and pyrrolo [2,3-B] pyridine protein kinase inhibitors

Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.

7H-pyrido[3,4-D]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors

Heterocyclic carbamate derivatives, their manufacture and use as pharmaceutical agents

Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer. 

Heterocyclic benzylamino derivatives, their manufacture and use as pharmaceutical agents

The present invention relates to novel amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I). 

Amide derivatives of 3-phenyl-dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents

Benzamide derivatives, their manufacture and use as pharmaceutical agents

Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

6-(2-alkyl-phenyl)-pyrido[2,3-D]pyrimidines useful as protein kinase inhibitors

The present invention relates to novel amide derivatives of 7-amino-3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I). 

Amide derivatives of 7-amino-3-phenyl-dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents

Compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates are disclosed. Also disclosed are methods for the preparation of the above-mentioned compounds, pharmaceutical compositions containing them, as well as the use of the above-mentioned compounds in the treatment, control or prevention of illnesses such as cancer.

Phthalazinone derivatives

The invention describes compounds of the general formula I a process for their manufacture, compositions containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. These compounds show activity as protein kinase inhibitors, in particular src family tyrosine kinase inhibitors, and may therefore be useful for the treatment of diseases mediated by said tyrosine kinases.

Pyrido[2,3-d]pyrimidine dichloro-phenyl derivatives

Compounds of the general formula (I) are presented which arevaluable therapeutics for the treatment of cancer and cancer related diseases.

Imidazole derivatives and their use as pharmaceutical agents

The invention describes compounds of the general formula I a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The compounds show activity as protein kinase inhibitors, in particular src family tyrosine kinase inhibitors, and may therefore be useful for the treatment of diseases mediated by said tyrosine kinases.

Pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents

Disclosed are novel pyrimido compounds that are inhibitors of Src family of tyrosine kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, hepatic and pancreatic tumors. Also disclosed are pharmaceutical compositions containing these compounds and methods of treating cancer.

Pyrimido compounds having antiproliferative activity

Compounds of formula I are described. These compounds are protein kinase inhibitors, in particular they inhibit the src family tyrosine kinases. Thus, these compounds are useful for the treatment of diseases mediated by src tyrosine kinases, including cell proliferative disorders such as cancer. Also described are methods of making and using compounds of formula I as well as pharmaceutical compositions containing these compounds.

Amino-substituted dihydropyrimido[4,5-D]pyrimidinone derivatives

A method of combating undesired plant growth in cereals, in particular winter cereals such as wheat and barley, which comprises treating the locus of the cereals with an effective amount of one or more compounds of formula I:in which R, Rand X&#x2014;W have the meaning given in the claims.

Method of combating undesired plant growth on cereals

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Penzberg, Germany

Stefan Scheiblich