Smithkline Beecham Corporation

Beecham Group Plc

Stefan Roland Woroniecki

Keith H Baggaley

Stephen W Elson

Richard M Hindley

John Thomas Sime

Stephen William Elson

Neville Hubert Nicholson

David Alan Yeandle

Janice Arnell

Esme Faith Hayes

A compound of formula (I), wherein R&equals;H or Na, or a salt thereof and an enzyme, obtainable from Streptomyces species, having clavulanic acid dehydrogenase activity which is capable of converting (I) into clavulanic acid.

Clavulanic acid dehydrogenase, preparation and use for the production of clavulanic acid

Enzymatic preparation of monic acids

Process for the preparation of pharmaceutically active thiazolidine

A compound having the formula (I): ##STR1## is described, together with salts thereof and an enzymatic process for converting such compounds into clavulanic acid. A process for the preparation of the compound of formula (I) and its salts is disclosed, together with intermediates for use therein. This process involves the use of a novel enzyme system to effect the desired cyclisation, which enzyme system is preferably derived from a micro-organism, in particular a species of Streptomyces.

Clavam derivatives and its enzymatic preparation

A compound having the formula (I): ##STR1## is described, together with salts thereof and an enzymatic process for converting such compounds into clavulanic acid. A process for the preparation of the compound of formula (I) and its salts is disclosed, together with intermediates for use therein. This process involves the use of a novel enzyme system to effect the desired cyclization, which enzyme system is preferably derived from a micro-organism, in particular a species of Streptomyces.

Novel clavam derivatives and methods of making same

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Betchworth, United Kingdom

Stefan Roland Woroniecki