Oxford University Innovation Ltd

Isis Innovation Limited

Stefan Piechnik

Matthew Robson

Stefan Neubauer

Rajarshi Banerjee

Qiang Zhang

Iulia Andreia Popescu

Vanessa Ferreira

Elizabeth Tunnicliffe

Andreas Greiser

Konrad Werys

Belen Rial

Evan Hann

A method and apparatus for enhancing magnetic resonance images to produce contrast-enhanced images without the need to administer contrast agent to a patient. The image processing apparatus utilises a trained machine learning algorithm as an image processor, preferably a generative adversarial network, to produce images from contrast agent-free magnetic resonance images with the produced images having similar appearance and better image quality and better pathological sensitivity and being able to differentiate more pathological conditions than actually acquired contrast-enhanced images.

Enhancement of medical images

A validation technique for quality assurance of quantitative MRI methods by comparing the measured magnetic properties of a phantom having a range of T1 and T2 values measured by an accelerated, clinically-practicable protocol with predicted values for that magnetic property calculated from a set of reference T1 and T2 values measured on the phantom. The prediction is based on a relationship between the values from the accelerated protocol and values from the reference measurements obtained by repeatedly scanning one or more phantoms.

Validation of quantitative magnetic resonance imaging protocols

Described herein are systems and methods for performing multi-parametric diagnosis for liver disease. Systems and methods as described herein can include positioning a subject-in association with a medical imaging device and using the medical imaging device to measure the subject's liver for extracellular fluid and iron content. Systems and methods as described herein can further include determining whether iron overload may be indicated or present from the measurement for iron content, and if indicated, correcting the measurement for extra cellular fluid. Systems and methods as described herein can further include measuring the liver for hepatic lipid content (HLC). Systems and methods as described herein can determine the presence or absence of liver disease from measurements obtained from a subject. In certain embodiments, the medical imaging device is a magnetic resonance (MR) scanner. In certain embodiments, the liver is measured for iron overload.

Multi-parametric magnetic resonance diagnosis and staging of liver disease

The present disclosure provides systems and methods for universal mapping of T1 in abdominal organs using cardiac gating. A region of interest is selected for mapping or imaging. A determination is made whether any one or more of heart associated motion, high heart rate and irregular heart beat are detected in the region of interest. A multi-pathway gating of T1 maps is then employed providing a universal method of T1 mapping of moving as well as non-moving visceral organs.

Systems and methods for gated mapping of T1 values in abdominal visceral organs

A shortened version of the MOLLI sequence (Sh-MOLLI) is described which generates rapid and high-resolution myocardial spin-lattice (T) maps. The Sh-MOLLI technique is based on a significant abbreviation of pre-existing TI sampling scheme combined with the use of processing logic to bypass the major side effects of the above sampling scheme abbreviation and distinguish between long and short Trelaxation times in order to conditionally utilize available TI samples for non-linear Tfitting.

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Oxford, United Kingdom

Stefan Piechnik