Kaleidos Pharma, Inc.

Applied Protein Sciences LLC

Stem Cell Pharmaceuticals, Inc.

Stefan Paskell

Daniel R Twardzik

Thomas S Felker

Andre Pernet

John M Reno

There is disclosed a novel genus of small peptides, much smaller than human TGF&#x3b1;, was discovered as having TGF&#x3b1; biological activity and therefore are useful as pharmacologic agents for the same indications as full length TGF&#x3b1; polypeptide. There is further disclosed that TGF&#x3b1; and consequently the genus of small peptides disclosed herein, was found to have therapeutic activity to stimulate hematopoiesis in patients undergoing cytotoxic cancer chemotherapy and to act as a cytoprotective agent to protect a patient undergoing cancer cytotoxic therapy from gastrointestinal (GI) side effects, such as mucositis and otherwise support the barrier function of the GI tract when it is harmed by cytotoxic therapy.

Loop peptide and TGF&#x3b1; for stimulating stem cell proliferation and migration

Disclosed are TGF-&#x3b1; polypeptides, related polypeptides, fragments and mimetics thereof useful in stimulating stem cell or precursor cell proliferation, migration and differentiation. The methods of the invention are useful to treat tissue injury as well as expand stem cell populations in, or obtained from, gastrointestinal, musculoskeletal, urogenital, neurological and cardiovascular tissues. The methods include ex vivo and in vivo applications.

TGF-&#x3b1; polypeptides, functional fragments and methods of use therefor

Disclosed are TGF-&agr; polypeptides, related polypeptides, fragments and mimetics thereof useful in stimulating stem cell or precursor cell proliferation, migration and differentiation. The methods of the invention are useful to treat tissue injury as well as expand stem cell populations in, or obtained from, gastrointestinal, musculoskeletal, urogenital, neurological and cardiovascular tissues. The methods include ex vivo and in vivo applications.

TGF-&agr; polypeptides, functional fragments and methods of use therefor

There is disclosed a novel genus of small peptides, much smaller than human TGF&agr;, was discovered as having TGF&agr; biological activity and therefore are useful as pharmacologic agents for the same indications as full length TGF&agr; polypeptide. There is further disclosed that TGF&agr; and consequently the genus of small peptides disclosed herein, was found to have therapeutic activity to stimulate hematopoiesis in patients undergoing cytotoxic cancer chemotherapy and to act as a cytoprotective agent to protect a patient undergoing cancer cytotoxic therapy from gastrointestinal (GI) side effects, such as mucositis and otherwise support the barrier function of the GI tract when it is harmed by cytotoxic therapy.

Loop peptide and TGF&agr; for stimulating stem cell proliferation and migration

Disclosed are TGF-60  mimetics that PEGylated TGF-&agr; polypeptides and PEGylated TGF-60  related polypetides or fragments thereof.

Disclosed are peptides related to human TGF-&agr;, having TGF-&agr; biological activity, which are useful for many of the indications that full-length TGF-&agr; polypeptide is useful. Also provided are methods of use of such peptides, as well as human TGF-&agr; and biologically related polypeptides. For example, methods for treating or preventing cachexia in subjects are provided as well as methods for stimulating hematopoiesis in patients undergoing cytotoxic chemotherapy. In addition, the use of TGF-&agr; related peptides to related neurodengenerative diseases is also provided. Methods of the invention also provide protection for patients undergoing cytotoxic therapy from side effects such as gastrointestinal (GI) mucositis.

Growing community of inventors

Bainbridge Island, WA, United States of America

Stefan Paskell