Carmeda Ab

Other

Novartis Ag

Novartis Vaccines and Diagnostics Srl

Teodorovic, Peter

Oscarson, Stefan

Stefan Oscarson

Karin Leontein

Robert Vestberg

Martina Lahmann

Paolo Costantino

Eva Koch

Peter Teodorovic

Johan Riesenfeld

Dagmar Pikas

There is provided inter alia an anticoagulant surface which surface has covalently bound thereto a plurality of fragments of heparin, wherein said fragments consist of 5-18 saccharide units and at least some of said plurality of fragments comprise polysaccharide sequence A, which surface catalyses the inhibition of FIIa and FXa by AT.

Immobilised biological entities

There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.

An oligosaccharide useful for a Meningitidis A vaccine contains a first mannose unit having a spacer in the alpha configuration at C-1, which spacer is capable of conjugating to a protein, and which is connected to a second mannose unit through a 1,6-linkage which connects C-6 of the first unit to C-1 of the second unit, wherein the 1,6-linkage comprises a phosphonate. Related methods of making such compounds, analogous compounds, or intermediates thereof are also disclosed.

Immunogens for meningitidis-A vaccines

Growing community of inventors

Stockholm, Sweden

Stefan Oscarson