Basf Aktiengesellschaft

Basf Se Corporation

Stefan Orsten

Christian Wulff

Alfred Oftring

Michael Rack

Michael Keil

Joachim Gebhardt

Peter Zehner

Hartwig Voss

Frederik Menges

Knut Kessel

David Cortes

Dirk Franke

G&uuml;nter Scherr

Helmut Zech

Thomas Bogenst&auml;tter

Rodney F Klima

Robert Leicht

Jochen Schröder

Hugues Vandenmersch

Jochen Schroeder

Tony Yegerlehner

A process for manufacturing 5,6-disubstituted-3-pyridylmethyl ammonium bromides (I), wherein wherein the symbols have the meaning given in formula (I), with bromine in the presence of a radical initiator in a solvent mixture comprising an aqueous phase and an organic phase, where the organic phase comprises a solvent selected from 1,2-dichloroethane, chlorobenzene, 1,2-dichlorobenzene, 1,3-dichlorobenzene, 1,4-dichlorobenzene and tetrachloromethane, and where the pH-value of the aqueous phase is from 3 to &#x3c;8, to obtain a 3-bromomethyl-5,6-disubstituted pyridine compound (III), wherein Y, Y, Z and Zhave the meanings given in formula (I), and

Process for manufacturing substituted 3-pyridylmethyl ammonium bromides

The invention relates to a process for preparing N-phosphono-methylglycine by reacting a hexahydrotriazine compound with a triacyl phosphite in an organic solvent, hydrolyzing the resulting phosphono compound after prior extraction into an aqueous phase and separation from the organic phase. The process avoids decomposition of the organic solvent during hydrolysis.

Method for producing N-phosphonomethylglycine

The present invention relates to a process for the recovery of N-phosphonomethylglycine from an aqueous mixture which contains N-phosphonomethylglycine, ammonium halides, and alkali metal or alkaline earth metal halides and optionally organic impurities in dissolved form, where The process according to the invention makes possible the recovery of the N-phosphonomethylglycine with simultaneous separation of the halide salts.

The present invention relates to a process for the preparation of N-phosphonomethylglycine by reacting a hexahydrotriazine derivative with a triacyl phosphite. The process gives N-phosphonomethylglycine in high yield and in a simple and inexpensive manner.

Process for the preparation of N-phosphonomethylglycine

Method for production of n-phosphonomethylglycine

A process for purifying creatine is described in which the creatine to be purified in the form free of water of crystallization is introduced into a saturated aqueous solution of creatine monohydrate, in which the creatine free of water of crystallization is dissolved with hydration, crystals of creatine monohydrate precipitate from the aqueous solution and these are separated off from the aqueous solution.

Process for purifying creatine

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Ellerstadt, Germany

Stefan Orsten