Gruenenthal Gmbh

Gruenethal Gmbh

Stefan Oberboersch

Bernd Sundermann

Beatrix Merla

Werner Guenter Englberger

Ruth Jostock

Melanie Reich

Stefan Schunk

Sabine Hees

Klaus Schiene

Babette-Yvonne Koegel

Hagen-Heinrich Hennies

Tieno Germann

Michael Engels

Hans Schick

Klaus Linz

Helmut Sonnenschein

Claudia Hinze

Birgitta Henkel

Edward Bijsterveld

Thomas Christoph

Elmar Josef Friderichs

Sven Kuehnert

Heinz Graubaum

Otto Aulenbacher

Valerie Sarah Rose

Michael Jonathan Lipkin

Corinna Sundermann

Gregor Bahrenberg

Achim Kless

Wolfgang Schroeder

Robert Frank

Michael Haurand

Jean De Vry

Fritz Theil

Michael Franz-Martin Engels

Timo Struenker

Derek John Saunders

Saskia Zemolka

Utz-Peter Jagusch

Petra Bloms-Funke

Sven Frormann

Dagmar Kaulartz

Thomas Tzschentke

Christa Kneip

Ellen Klegraf

Stephan Schunk

Heinze Graubaum

Elmark Friderichs

Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them.

Process or preparing spirocyclic cyclohexane compounds, compositions containing such compounds and method of using such compounds

Process for preparing spirocyclic cyclohexane compounds, compositions containing such compounds and method of using such compounds

Substituted sulfonamide compounds with bradykinin receptor (B1R) modulating activity; processes for the preparation thereof, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or inhibit pain and/or other disorders and/or disease states.

Substituted sulfonamide compounds

Substituted sulfonamide compounds corresponding to the formula I processes for the preparation thereof, pharmaceutical compositions containing these compounds and the use of substituted sulfonamide compounds for the preparation of pharmaceutical compositions for treating pain and other conditions at least partly mediated via the bradykinin 1 receptor.

Substituted spiro-amide compounds corresponding to formula I in which R5 through R8, D, X, Y and Z have defined meanings, processes for preparing such spiro-amide compounds, pharmaceutical compositions containing such compounds, and methods of using such spiro-amide compounds for treating and/or inhibiting disorders or disease states mediated at least in part by the bradykinin 1 receptor.

Substituted spiro-amide compounds

Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment or inhibition of pain and/or various disorders or disease states.

Substituted sulfonamide compounds corresponding to formula I: processes for the preparation thereof, pharmaceutical compositions containing these compounds, and the use of such substituted sulfonamide compounds in pharmaceutical compositions for the treatment and/or inhibition of pain and other conditions at least partly mediated by the bradykinin 1 receptor.

Substituted tetrahydroimidazopyridine compounds corresponding to formula I: in which R, Rand Rhave defined meanings, processes for preparing such compounds, pharmaceutical compositions containing such compounds, and the use of such compounds for treating or inhibiting pain, epilepsy, migraine, anxiety or urinary incontinence.

Substituted tetrahydroimidazopyridine compounds and the use thereof in the treatment of pain and other conditions

Substituted spiroamine compounds corresponding to the formula (I) In which m, n, o, p, Q, r, s, t, R, R, R, R, R, R, R, R, R, R, R, R, Rand Rhave defined meanings; a process for the preparation of such compounds, pharmaceutical compositions containing such compounds and the use of substituted spiroamines for the treatment or inhibition of pain and/or other conditions mediated by the bradykinin 1 receptor.

Substituted spiroamine compounds

Substituted sulfonamide compounds corresponding to formula I processes for the preparation thereof, pharmaceutical compositions containing such compounds, and the use of such compounds for treating and/or inhibiting pain or other conditions at least partly mediated by the bradykinin 1 receptor.

Substituted sulfonamide compounds corresponding to the formula I wherein m, n, p, Q, R, R, R, R, X, Y and Z have the respective meanings defined herein, pharmaceutical compositions containing such compounds, a process for their preparation, and the use of such compounds for the treatment and/or inhibition of pain and other conditions mediated by bradykinin receptor 1 (B1R) and/or bradykinin receptor 2 (B2R).

Substituted sulfonamide compounds corresponding to the formula I' wherein m, n, p, X, Y, Z, R1, RA and RB have specified meanings, processes for their preparation, pharmaceutical compositions containing these compounds, and the use of these substituted sulfonamide compounds for the treatment and/or inhibition of pain or other conditions.

Substituted sulfonamide compounds having bradykinin 1 receptor activity and use thereof as medicaments

Sulfonylated tetrahydroazolopyrazine compounds corresponding to the formula I wherein R, R, R, R, R, R, R, R, R, R, R, A, B, W, Wand Whave the meanings defined herein, pharmaceutical compositions containing such compounds, a method for the preparation of such compounds, and the use of such compounds for treating or inhibiting various types of pain and/or other conditions mediated at least in part by the bradykinin 1 receptor (B1R).

Sulfonylated 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine compounds and their use as pharmaceuticals

Spirocyclic cyclohexane compounds corresponding to formula I a process for manufacturing such compounds, pharmaceutical compositions that contain such compounds, and the use of such spirocyclic cyclohexane compounds for the production of pharmaceuticals, and particularly for the treatment of pain.

Spirocyclic cyclohexane compounds with analgesic activity

Substituted sulfonamide compounds corresponding to formula I: a process for their preparation, pharmaceutical compositions comprising such compounds, and the use of such substituted sulfonamide compounds in pharmaceutical compositions for the treatment of pain or other disorders or diseases that are mediated at least in part by B1R receptors.

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Aachen, Germany

Stefan Oberboersch