Oxford University Innovation Ltd

Stefan Neubauer

Charalambos Antoniades

Keith Channon

Evangelos Oikonomou

Matthew Robson

Stefan Piechnik

Rajarshi Banerjee

Elizabeth Tunnicliffe

Alexios Antonopoulos

Belen Rial

The present invention describes a new functional biomarker of vascular inflammation and its use in predicting all-cause or cardiac mortality. The invention also provides a method for stratifying patients according to their risk of all-cause or cardiac mortality using data gathered from a computer tomography scans of a blood vessel to determine a specific combination of structural and functional biomarkers of vascular inflammation and disease.

Method for predicting cardiovascular risk

Method of assessing the level of vascular inflammation

Methods for volumetric characterisation of perivascular adipose tissue use data collected by computed tomography (CT) scanning. The volumetric characterisation of perivascular adipose tissue allows the inflammatory status of underlying blood vessels to be established by CT scanning. This is of use in the diagnosis, prognosis and treatment of coronary and vascular disease.

Method for characterisation of perivascular tissue

Described herein are systems and methods for performing multi-parametric diagnosis for liver disease. Systems and methods as described herein can include positioning a subject-in association with a medical imaging device and using the medical imaging device to measure the subject's liver for extracellular fluid and iron content. Systems and methods as described herein can further include determining whether iron overload may be indicated or present from the measurement for iron content, and if indicated, correcting the measurement for extra cellular fluid. Systems and methods as described herein can further include measuring the liver for hepatic lipid content (HLC). Systems and methods as described herein can determine the presence or absence of liver disease from measurements obtained from a subject. In certain embodiments, the medical imaging device is a magnetic resonance (MR) scanner. In certain embodiments, the liver is measured for iron overload.

Multi-parametric magnetic resonance diagnosis and staging of liver disease

The present disclosure provides systems and methods for universal mapping of T1 in abdominal organs using cardiac gating. A region of interest is selected for mapping or imaging. A determination is made whether any one or more of heart associated motion, high heart rate and irregular heart beat are detected in the region of interest. A multi-pathway gating of T1 maps is then employed providing a universal method of T1 mapping of moving as well as non-moving visceral organs.

Systems and methods for gated mapping of T1 values in abdominal visceral organs

Growing community of inventors

Headington, United Kingdom

Stefan Neubauer