Basf Aktiengesellschaft

Stefan Mueller

Hans Theobald

Uwe Kardorff

Andreas Kling

Bernd Wolf

Christoph Kuenast

Volker Harries

Peter Hofmeister

Bernd Janssen

Kurt Ritter

Harald Rang

Rainer Schlecker

Cynthia A Romerdahl

Gerhard Keilhauer

Ulrich Traugott

This invention relates to 1-amino-3-phenoxy-propane-derivatives of formula 1: ##STR1## (in which A, B, R, R.sup.x, X and Z are defined as in the specification described) and methods for their preparation. These compounds may be used as modulators of multidrug resistance in cancer chemotherapy and for circumvention of resistance in the treatment of malaria.

1-amino-3-phenoxy propane derivatives as modulator agents and their

3-Isoxazolylphenyl compounds Ia and Ib ##STR1## where R is halogen; alkyl; haloalkyl; alkoxy; haloalkoxy; alkenyl; haloalkenyl; unsubstituted or substituted phenylethenyl; alkynyl; cycloalkyl; aryl; hetaryl; CO.sub.2 R.sup.6 or CONR.sup.7 R.sup.8,

3-Isoxazolylphenyl compounds, their preparation and their use

3-Isoxazolylbenzyl esters of the general formulae Ia and Ib ##STR1## where R is halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.2 --C.sub.4 -alkenyl, C.sub.2 -C.sub.4 -haloalkenyl, C.sub.2 -C.sub.4 -alkynyl, C.sub.2 -C.sub.4 -haloalkynyl, unsubstituted or substituted phenylethenyl, C.sub.3 -C.sub.8 -cycloalkyl, aryl, hetaryl, CO.sub.2 R.sup.3 or CONR.sup.4 R.sup.5,

3-isoxazolylbenzyl esters, their preparation and their use

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Speyer, Germany

Stefan Mueller