Janssen Pharmaceutica Nv

Princeton University

Mrl Cambridge Esc

Stefan McCarver

Steven D Goldberg

Steven P Meduna

Alexander Valdes

Xiaohua Xue

Timothy B Rhorer

Steven Loskot

Douglas Behenna

Connor L Martin

John M Keith

Craig R Woods

Alexander Raymond Rovira

Deane Gordon

Luke E Hanna

David MacMillan

Daniel Novoa

David A Kummer

Jennifer Diane Venable

Brock T Shireman

Dongpei Wu

Virginia M Tanis

Dann LeRoy Parker, Jr

Charlotte Pooley Deckhut

Rob C Oslund

Dougas C Behenna

Kristen Song

Alexander Rovira

Olugbeminiyi O Fadeyi

Jacob Geri

James Oakley

Tao Wang

Tamara Reyes-robles

Frances Paola Rodriguez-rivera

David WC Macmillan

The present application discloses compounds having the following formula: or pharmaceutically acceptable salts thereof, wherein R, R, R, and Rare defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

Imidazopyridazine IL-17 inhibitor compounds

The present application discloses compounds having the following formula: or pharmaceutically acceptable salts thereof, wherein R, R, R, Rand Rare defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

Imidazopyridazines as modulators of IL-17

Synthetic methods are described herein operable to efficiently produce a wide variety of molecular species through conjugate additions via decarboxylative mechanisms. For example, methods of functionalization of peptide residues are described, including selective functionalization of peptide C-terminal residues. In one aspect, a method of peptide functionalization comprises providing a reaction mixture including a Michael acceptor and a peptide and coupling the Michael acceptor with the peptide via a mechanism including decarboxylation of a peptide reside.

Decarboxylative conjugate additions and applications thereof

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San Diego, CA, United States of America

Stefan McCarver