Hoechst Aktiengesellschaft

Stefan M Ullner

Heiner Glombik

Gerhard Breipohl

Axel Walch

Alfons Enhsen

Werner Thorwart

Klaus U Weithmann

Michael Ahlers

Ruth Raiss

Rolf Graeve

G Unther Wess

G Unter M Uller

Wendelin Frick

Crosslinked, nitrogen-containing vinyl copolymers having units of the formula I ##STR1## and physiologically tolerated salts thereof, in which, in formula I, A1, A2, R, w, x, y and z have the meanings given, a process for their preparation and the use of the compounds as medicaments, active compound carriers and foodstuff auxiliaries are described.

Crosslinked nitrogen-containing vinyl copolymers processes for their

Phosphonoacetic acid derivatives and their use for treating degenerative joint disorders Compounds of the formula I ##STR1## are suitable for producing pharmaceuticals for the treatment and prophylaxis of degenerative joint disorders, of rheumatic disorders accompanied by cartilage breakdown, such as rheumatoid arthritis, joint trauma and chondrolysis as a consequence of prolonged immobilization of the joint, of inflammations, septic shock, disorders with impaired leukocyte adhesion, disorders caused by an elevated concentration of tumor necrosis factor alpha, such as cachexia or Crohn's disease.

Phosphonoacetic acid derivatives and their use for treating degenerative

Peptides with an insulin-like action, of formula I: ##STR1## in which G is a hydrogen atom, an amino add residue, or a monosubstituted or polysubstituted amino acid; D is an amino acid residue, a phosphoamino acid residue, a monosaccharide residue, or a covalent bond; E is --NH--(CH.sub.2).sub.n --NR.sup.5.sub.2, a glycerol residue, or --NH--(CH.sub.2).sub.p --R.sup.6 --R.sup.7 ; R.sup.1 is (C.sub.1 -C.sub.4)-alkyl or .dbd.O; R.sup.2 is a sulfhydryl protecting group, (C.sub.1 -C.sub.3)-alkyl, or a hydrogen atom; R.sup.3 and R.sup.4, independently of one another, are a hydrogen atom or methyl; R.sup.5, each being identical or different, is a hydrogen atom, 1 to 6 monosaccharide residues, or 1 to 6 monosubstituted or polysubstituted monosaccharide residues; R.sup.6 is O PO.sub.4 H, PO.sub.2 H, NHCOO, S or OCOO; R.sup.7 is a hydrogen atom, 1 to 6 monosaccharide residues, or 1 to 6 monosubstituted or polysubstituted monosaccharide residues; w is an integer 1 or 2; their preparation and use for treatment of diabetes mellitus or insulin-independent diabetes.

Peptides with an insulin-like action

Ethylenically unsaturated bile acid derivatives of the formula I

Ethylenically unsaturated bile acid derivatives, processes for their

Growing community of inventors

Hochheim am Main, Germany

Stefan M Ullner