Synta Pharmaceuticals Corporation

Stefan M Schweizer

Weiwen Ying

Dinesh U Chimmanamada

Shijie Zhang

Joseph A Burlison

Junghyun Chae

Minghu Song

Lijun Sun

Zachary Demko

David James

Teresa Kowalczyk-Przewloka

Shoujun Chen

Teresa Przewloka

Jun Jiang

Zhi-Qiang Xia

Christopher Borella

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a pharmaceutical composition comprising such a compound.

Triazole compounds that modulate HSP90 activity

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to the use of a substituted triazole compound of the invention, or a composition comprising such a compound in the preparation of a medicament for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof.

Triazole compounds that modulate Hsp90 activity

The present invention is directed to compounds represented by structural formula (I), or a pharmaceutically acceptable salt or a transition metal chelate, coordinate or complex thereof or a transition metal chelate, coordinate or complex of a deprotonated form of the compound. Pharmaceutical composition and method of use for these compounds are also included. 

Sulfonylhydrazide compounds for treating proliferative disorders

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Memphis, TN, United States of America

Stefan M Schweizer