Macropore, Inc.

Artes Medical, Inc.

Macropore Biosurgery, Inc.

Stefan M Lemperle

Christopher J Calhoun

Corbett W Stone

Brian S Kelleher

Ralph Holmes

Steven R Cohen

Horst Fichtner

J Peter Amis

Russell J Anderson

Gerhard Quelle

David Lipsitz

One aspect of the present invention is a connective tissue distraction device comprising: a first transmitting structure for transmitting force to a first tissue region and a second transmitting structure for transmitting force to a second tissue region by contact with bone, and an expansion device for exerting force distracting the first transmitting structure from the second transmitting structure. At least one of the first transmitting device, the second transmitting device and the expansion structure comprises in whole or in part a biodegradable, bioerodible or bioresorbable material.

Partially resorbable connective tissue distraction devices and techniques

Microspheres to be implanted into a patient are metered and mixed with fluids, cells, or tissues withdrawn from the patient's own body, and reinserted into the patient's body to achieve augmentation, repair or other treatment of the patient's tissue.

Methods of administering microparticles combined with autologous body components

A resorbable, flexible implant in the form of a continuous macro-porous sheet is disclosed. The implant is adapted to protect biological tissue defects, especially bone defects in the mammalian skeletal system, from the interposition of adjacent soft tissues during in vivo repair. The membrane has pores with diameters from 20 microns to 3000 microns. This porosity is such that vasculature and connective tissue cells derived from the adjacent soft tissues including the periosteum can proliferate through the membrane into the bone defect. The thickness of the sheet is such that the sheet has both sufficient flexibility to allow the sheet to be shaped to conform to the configuration of a skeletal region to be repaired, and sufficient tensile strength to allow the sheet to be so shaped without damage to the sheet. The sheet provides enough inherent mechanical strength to withstand pressure from adjacent musculature and does not collapse.

Resorbable, macro-porous non-collapsing and flexible membrane barrier for skeletal repair and regeneration

A surgical device for expanding and viewing tissue is disclosed. The surgical device includes a handle, an insertion probe, and at least one window disposed within the insertion probe. The handle has a proximal end and a distal end, and the handle is sized and shaped to be held by a surgeon. The insertion probe has a proximal end, a distal end, and a longitudinal axis extending between the proximal end and the distal end. The proximal end of the insertion probe is removably attached to the distal end of the handle. The window extends along a length of the longitudinal axis, and has an opening that is sufficient in size to allow tissue to prolapse through the window and into the insertion probe.

Urethra surgical device

A resorbing, flexible implant in the form of a continuous macro-porous sheet ( ) is disclosed. The implant is adapted to protect biological tissue defects, especially bone defects in the mammalian skeletal system, from the interposition of adjacent soft tissues during in vitro repair. The membrane ( ) has pores with diameters from 20 microns to 3000 microns. This porosity is such that vasculature, and connective tissue cells derived from the adjacent soft tissues including the periosteum, can proliferate through the membrane into the bone defect. The thickness of the sheet is such that the sheet has both sufficient flexibility to allow the sheet to be shaped to conform to the configuration of a skeletal region to be repaired, and sufficient tensile strength to allow the sheet to be so shaped without damage to the sheet. The sheet provides enough inherent mechanical strength to withstand pressure from adjacent musculature, and does not collapse.

Membrane with tissue-guiding surface corrugations

Resorbable, macro-porous, non-collapsing and flexible membrane barrier

Growing community of inventors

La Jolla, CA, United States of America

Stefan M Lemperle