Janssen Vaccines & Prevention B.v.

Genmab A+s

Complix Nv

Stefan Loverix

Ignace Lasters

Philippe Alard

Paul Parren

Janine Schuurman

Ronald Vogels

Aran Frank Labrijn

Katarina Radosevic

Johan Desmet

Jan Willem Meijberg

Antonietta Impagliazzo

Robert H E Friesen

Klaartje Somers

Jan Van De Winkel

Maria Henderikx

Robert Heinz Edward Friesen

Mark Vaeck

Jau Van De Winkel

Lgnace Laster

Sabrina Deroo

Jürgen Debaveye

Jan Wilem Meijberg

Maria Paulina Henderikx

Provided herein are polypeptides that are capable of crossing the cellular membrane and entering into the intracellular environment, which polypeptides are suitable for use in prophylactic, therapeutic or diagnostic applications as well as in screening and detection. Nucleic acids encoding such polypeptides; methods for preparing such polypeptides, host cells expressing or capable of expressing such polypeptides, compositions, and in particular pharmaceutical compositions, that comprise such polypeptides, in particular for prophylactic, therapeutic or diagnostic purposes are also provided.

Polypeptides capable of cellular internalization

The present invention relates to positions in the constant region of antibodies, in particular the CH3 region of IgG4, which affect the strength of CH3-CH3 interactions. Mutations that either stabilize or destabilize this interaction are disclosed.

Antibody variants having modifications in the constant region

The present disclosure provides influenza hemagglutinin stem domain polypeptides comprising (a) an influenza hemagglutinin HA1 domain that comprises an HA1 N-terminal stem segment, covalently linked by a linking sequence of 0-50 amino acid residues to an HA1 C-terminal stem segment, and (b) an influenza hemagglutinin HA2 domain, wherein on or more amino acids in the HA2 domain have been mutated. Also provided are nucleic acids encoding the polypeptides, compositions comprising the polypeptides and/or nucleic acid molecules, as well as methods of their use, in particular in the detection, prevention and/or treatment of influenza.

Influenza virus vaccines and uses thereof

The application provides Alphabodies that specifically bind to IL-23, as well as to polypeptides that comprise or essentially consist of such Alphabodies. Also provided herein are nucleic acids encoding such Alphabodies; to methods for preparing such Alphabodies and polypeptides; and in particular to pharmaceutical compositions, that comprise such Alphabodies, polypeptides, nucleic acids and/or host cells.

Polypeptides specifically binding to IL-23

Growing community of inventors

Ternat, Belgium

Stefan Loverix