Medivir Ab

Stefan Lindstrom

Christer Sahlberg

Hans Kristian Wallberg

Christian Sund

Xiao-Xiong Zhou

Lourdes Salvador Oden

Horst Wahling

Dmitry Antonov

Genaidy Kalyanov

Lotta Naeslund

Nils Gunnar Johansson

Katarina Jansson

Lourdes Salvador

Nathalie Roue

Compounds of the formula Z: where; A is CH or N; Ris a substituent to a carbon atom in the ring containing A selected from &#x2014;S(&#x2550;O)Ra, where Ra is &#x2014;C-Calkyl, &#x2014;ORx, &#x2014;NRxRx, &#x2014;NHNRxRx, &#x2014;NHNHC(&#x2550;O)ORx, &#x2014;NRxOH; &#x2014;C(&#x2550;O)&#x2014;Rb, where Rb is &#x2014;CT-C4-alkyl, ORx, &#x2014;NRxRx, &#x2014;NHNRxRx, &#x2014;NHC-C-alkyl-C(&#x2550;O)Orx &#x2014;NRxRc, where Rc is H, C-Calkyl, &#x2014;NRxRx; &#x2014;C(=0)Rd, &#x2014;CN, S(&#x2550;O)pRx, where Rd is Rd is C1-C4-alkyl, &#x2014;ORx, &#x2014;NRxRx C-C-alkyl-O&#x2014;C1-C3-alkylC(&#x2550;O)ORx, &#x2014;C-C-alkyl-COORx; &#x2014;C-Calkyl-OH or C-Calkyl ethers or esters thereof (O&#x2014;C-Calkyl)q-O&#x2014;Rx a 5 or 6 membered aromatic ring having 1-3 hetero atoms p is 1 or 2; Rx is independently selected from H, C-Calkyl or acetyl; or a pair of Rx can together with the adjacent N atom form a ring; L is -0-, &#x2014;S(&#x2550;O)&#x2014;, or &#x2014;CH&#x2014;, where r is 0, 1 or 2; R-Rare substituents as defined in the specification; X is &#x2014;(CRR')n-D-(CRR&#x2032;)m-; D is a bond, &#x2014;NR&#x2014;, -0-, &#x2014;S&#x2014;, &#x2014;S(=0)- or &#x2014;S(=0)-; and pharmaceutically acceptable salts and prodrugs thereof, have utility as HIV antivirals. 

Non-nucleotide reverse transcriptase inhibitors

This invention relates to non-nucleoside reverse transcriptase inhibitors active against HIV-1 and having an improved resistance and pharmacokinetic profile. The invention further relates to novel intermediates in the synthesis of such compounds and the use of the compounds in antiviral methods and compositions.

Non-nucleoside reverse transcriptase inhibitors

Prodrugs

Growing community of inventors

Uppsala, Sweden

Stefan Lindstrom