Symrise Ag

Stefan Lambrecht

Walter Kuhn

Erich Dilk

Marcus Eh

Marcus Betzer

Dietmar Schatkowski

Johannes Panten

Manuel Pesaro

Jens-Michael Hilmer

Alexander Steinbüchel

Wilhelm Wiedmann

Daniela Knoop

Jens Kroll

Gunda Hansen

Christian Fleige

Susanne Borchert

Detlef Geisel

Willi Wiedmann

The present invention relates to a method for the stereo selective production of a trans-diol or a cis-diol or a hydroxyketone comprising the step(s) (i) conversion of a trans-diol or a cis-diol to a hydroxyketone and/or (ii) conversion of a hydroxyketoneto a cis-diol or a trans-diol, catalyzed by an enzyme, which is encoded by a nucleic acid sequence of SEQ ID NO: or wherein the enzyme comprises an amino acid sequence of SEQ ID NO: 2. The present invention also relates to the use of an enzyme encoded by a nucleic acid sequence of SEQ ID NO: 1 or wherein the enzyme comprises an amino acid sequence of SEQ ID NO: 2 for the conversion of a trans-diol to a cis-diol or for the conversion of a trans-diol or a cis-diol to a hydroxy ketone and/or the conversion of a hydroxyketone to a trans-diol or a cis-diol.

Biotechnological production of diols

The present invention primarily relates to the use of one or more stereoisomers of the compound of formula (I) as described herein for modifying and/or enhancing the olfactory impression of one or more fragrances with a lily of the valley scent. The invention further relates to a new mixture comprising or consisting of one or more stereoisomers of the compound of formula (I) as described herein and two or more stereoisomers of the compound of formula (II) as described herein with a weight ratio of the stereoisomers of the compounds of formula (II) as described herein, fragrance compositions comprising or consisting of a mixture as described herein, perfumed products containing mixtures or fragrance composition as described herein, and a process for modifying and/or enhancing the lily of the valley scent of a compound of formula (II) as described herein, respectively for preparing a perfumed product as described herein.

Use of ambrocenide&#xae; for intensifying a lily of the valley scent

The present invention relates in particular to a mixture comprising the compound of formula (Ia) as described herein, wherein the mixture is free or essentially free of the compound of formula (Ib) as described herein, preferably of the compounds of formulae (Ib) and furthermore (Ic) and/or (Id) as described herein. The invention further relates to a method for manufacturing said mixture, fragrance substance compositions containing or consisting of said mixture, perfumed products containing said mixtures or fragrance substance compositions, and various methods and uses for imparting, modifying and/or enhancing certain odour notes.

Blends containing enantiomerically pure Ambrocenide&#xae;

The present invention relates in particular to a mixture comprising or at least essentially consisting of compound of formula (Ia) and (beta,beta-(4aR,5R,7aS,9R)-octahydro-2,2,5,8,8,9a-hexamethyl-4H-4a,9-methanoazuleno(5,6-d)-1,3-dioxole) of the formula (Ib), wherein the weight ratio of the compound of the formula (Ia) to the compound of the formula (Ib) in the mixture is in the range from 90:10 to 99:1. The present invention further relates to a method for producing such a mixture, to new odorant and/or aroma substance compositions, and to the use of a mixture of the invention (a) for masking or diminishing the one or more unpleasant olfactory impressions of one or more unpleasantly smelling substances, and/or (b) for intensifying the one or more pleasant olfactory impressions of one or more pleasantly smelling substances.

Mixtures having (4aR,5R,7aS,9R)-octahydro-2,2,5,8,8,9a-hexamethyl-4H-4a,9-methanoazuleno(5,6-d)-1,3-dioxole)(Ambrocenide)

The present invention is concerned with methods for producing vanillin, feroyl-CoA, ferulic acid, coniferyl aldehyde and/or coniferyl alcohol. Also, the invention relates to microorganisms useful in such production method, and to the construction of such microorganisms.

Microorganisms and methods for producing substituted phenols

The present invention relates to a mixture comprising or consisting of

Mixture of fragrance compounds

Growing community of inventors

Hehlen, Germany

Stefan Lambrecht