I-property Holding Corp.

Stefan Klocke

Alexander Stuck

Harald Walter

Thomas Gering

Paul Glendenning

A solid pharmaceutical dosage form has micro- or nanostructures impressed on the surface thereof or an interface thereof. The dosage form includes a suitable quantity and distribution of ingredients, such as one or more dyes, so as to enhance the optical contrast effect caused by the micro- or nanostructures so that the micro- or nanostructures are observable by the human eye and thereby able to provide anti-counterfeiting characteristics to the dosage form.

Manufacturing solid pharmaceutical dosage forms with visible micro- and nanostructured surfaces and micro- and nanostructured pharmaceutical dosage form

This inventive method assures the authenticity of drugs or other valuable substances that reside within product containers, such as syringes. The method includes initially measuring the 3D topology of the glass surface while determining the distance to the glass surface. Thereafter, a desired 3D code is written below the glass surface with a pulsed laser system. The written 3D code is readable using optical coherence topography (OCT) or parallel optical coherence tomography (pOCT) to verify the authenticity of the product container. A system uses this method with a plurality of syringes held within a tray, and a writing apparatus that moves relative to the tray to write a predetermined 3D code on each of the syringes held in the tray, during processing of the syringes along a process line while in the tray.

3D laser coding in glass

The present invention relates to a method for the authentication of dosage forms such as tablets, in particular pharmaceutical tablets, by reading, i.e. detecting, code structure from the tablet, reading additional information from the package or on an information sheet, and then comparing the readings to verify authenticity. The code structure may be randomized on a plurality of tablets disposed in identifiable locations in a shared package such that the detected code structures define a unique digital signature for the package of tablets.

Method for the authentication of dosage forms

The present invention relates to a verification method for tracking and tracing tablets, particularly pharmaceutical tablets. It further relates to a visible secure marking or information that is a part of such tablet (). The invention further relates to tablets suitable for such verification method, processes for manufacturing such tablets, and methods for reading the information.

Secure tracking of tablets

A method of tracking and tracing tablets, in particular pharmaceutical tablets, includes reading, i.e. detecting, code structure from the tablet, reading additional information from the package on an information sheet, and then comparing the readings to verify authenticity. The code structure may be two-dimensional or three-dimensional. The detected code may further be compared with information stored in a database.

A pharmaceutical dosage form [] has reduced susceptibility to counterfeiting, due to the forming directly thereon of a pattern or base layer [] of a Moir&#xe9; pair, wherein a Moir&#xe9; effect is visually observable by looking through a revealing layer [] positioned closely to and superimposed on the base layer []. The pattern fanned on the pharmaceutical dosage form [] may be formed by embossing, oblation, inkjet printing, or tampon printing. The revealing layer [] of the Moir&#xe9; pair can be part of a blister package containing the pharmaceutical dosage form [], so that the Moir&#xe9; effect is observable while looking at the pharmaceutical dosage form [] as it remains within the package.

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Karlsruhe, Germany

Stefan Klocke