Ge Healthcare Bio-Sciences Ab

Cytiva Sweden Ab

Stefan Kjell Eriksson

John Davis

Andreas Bergstrom

Roger Nordberg

Kyril Dambuleff

Mats O Hansson

The present invention relates to methods for conducting maintenance on chromatography columns used in industrial-scale chromatography. In particular, the invention is concerned with safer methods for performing maintenance on such columns, such as cleaning and replacing bed supports, distributors, nozzles, O-rings and other column components, by the use of a handling device to support, lift, carry and manipulate such column components.

Method for conducting maintenance on a chromatography column

The invention discloses a piston for a process column, said piston comprising a top side and a bed contact side, wherein said top side comprises a drainage trench.

Piston and process column

A chromatography column including: a tubular housing; a first end unit removably connected to a first end of the tubular housing; a second end unit removably connected to a second end of the tubular housing; an adaptor assembly movable within said tubular housing; an adaptor rod connected to said adaptor assembly, which adaptor rod is arranged to extend through an opening in the first end unit; a filter removably connected to the adaptor assembly; and a frame connected to said tubular housing for supporting the column on a floor. At least an actuating means is arranged on the frame, so that the column can be lifted and lowered in a substantially vertical direction.

Chromatography column and method of conducting maintenance on a chromatography column

An adaptor for a chromatography column, the adaptor comprising a substantially circular bottom plate provided with an end surface; a ring shaped wall element arranged at the periphery of the bottom plate. The bottom plate and the wall element having a common axis and the adaptor is provided with a filter connection arrangement for removably connecting a filter on the end surface of the bottom plate of the adaptor.

Adaptor for a chromatography column

A chromatographic column that includes a distributor plate secured to a backing plate of the chromatography column without the need for releasable fixing means such as screws or bolts, by employing a negative pressure or vacuum to affix the distributor to the backing plate.

Method and arrangement for securing a distributor plate to a backing plate of a chromatography column

A chromatography column and method of maintenance is described which does not require the use of a hoist or crane for disassembly. The method provides improved operator safety by reducing the need for the operator to work below a suspended or supported load within the column. Furthermore, the removal or replacement of column components is facilitated by providing access to the interior of the column and by the provision of a handling device.

Chromatography column and maintenance method

Chromatography column and method of maintenance

A method of maintenance of a chromatography column is described which does not require the use of a hoist or crane for disassembly. The method provides improved operator safety by reducing the need for the operator to work below a suspended or supported load within the column. The provision of guide elements which can be reversibly attached to the column facilitates removal or insertion of column components.

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Uppsala, Sweden

Stefan Kjell Eriksson