Morphosys Ag

Stefan Haertle

Stefan Steidl

Achim Knappik

Christian Frisch

Sebastian Jaeger

Daniela Daubert

Amgad Shebl

Stephane Leclair

The present invention provides antibodies and fragments thereof that specifically detect the complex of a specific cognate antigen-binding moiety, in particular antibodies, and its antigen. The antibodies of the present disclosure do not bind either said cognate antigen binding moiety or said antigen alone and this can be used e.g. to directly detect antigen-bound antigen-binding moieties. Further disclosed are methods for production and use of said antibodies and antibody fragments.

Complex-specific antibodies and antibody fragments and its use

The present disclosure provides a method to express and purify polypeptides and proteins. In the present disclosure the use of lysozyme as a fusion partner is disclosed. Furthermore, purification methods to isolate lysozyme-tagged polypeptides and proteins via lysozyme-specific antibodies are described. More specifically, the present disclosure provides a method to express and purify monomeric polypeptides and proteins by using lysozyme as a tag.

Use of lysozyme as a tag

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Mammendorf, Germany

Stefan Haertle